连钱草的化学成分、药理作用研究进展及其质量标志物的预测分析  

Research progress on chemical constituents and pharmacological effects of Glechomae Herba and prediction of its Q-markers

作　　者：张倩 韩竹箴 谷丽华[1,2] 王峥涛 ZHANG Qian;HAN Zhu-zhen;CU Li-hua;WANG Zheng-tao(MOE Key Laboratory for Standardization of Chinese Medicines,SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines,Institute of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai R&D Center for Standardization of Chinese Medicines,Shanghai 201203,China)

机构地区：[1]上海中医药大学中药研究所中药标准化教育部重点实验室国家中医药管理局中药新资源与质量评价重点实验室,上海201203 [2]上海中药标准化研究中心,上海201203

出　　处：《中国中药杂志》2023年第8期2041-2058,共18页China Journal of Chinese Materia Medica

基　　金：国家药典委标准项目(2018Z003);上海市技术标准项目(21DZ2202100)。

摘　　要：连钱草为唇形科植物活血丹Glechoma longituba的地上部分,为利水渗湿、利尿通淋药,因其在治疗结石症方面展现出良好的疗效而备受关注。近年来随着化学和药理学研究的不断深入,发现连钱草还具有抗菌、抗炎、抗氧化、抗血栓、保肝利胆、抗肿瘤和降脂、降糖等作用;其主要化学成分为黄酮类、萜类、苯丙素类、挥发油类和有机酸类。该文对连钱草的化学成分、药理作用进行归纳,并结合植物亲缘关系,基于化学成分特征性、有效性、药动学及作为指标成分的可测性等4个方面的考量,归纳出熊果酸、咖啡酸、迷迭香酸、木犀草素-7-O-二葡萄糖醛酸苷、芹菜素及其7-O-二葡萄糖醛酸苷、大波斯菊苷及连钱酮等可作为连钱草质量控制的候选质量标志物。Glechomae Herba, the dried aerial part of Glechoma longituba(Labiatae), has the effects of promoting urination, draining dampness, and relieving stranguria. It has received wide attention in recent years owing to the satisfactory efficacy on lithiasis. Amid the in-depth chemical and pharmacological research, it has been found that Glechomae Herba has antibacterial, anti-inflammatory, antioxidant, antithrombotic, hepatoprotective, cholagogic, antitumor, hypoglycemic, and lipid-lowering effects. The main chemical constituents are volatile oils, flavonoids, terpenoids, phenylpropanoids, and organic acids. This paper summarized the chemical constituents and pharmacological effects of Glechomae Herba. Based on genetic relationship of plants, the characteristics, efficacy, and pharmacokinetics of the chemical constituents, and the potential of these constituents as quality markers(Q-markers), it was summed up that ursolic acid, caffeic acid, rosmarinic acid, luteolin-7-O-diglucuronide, apigenin, apigenin-7-O-diglucuronide, apigetrin, and glechone can be the candidate Q-markers of Glechomae Herba.

关 键 词：连钱草 活血丹 质量标志物 化学成分 药理作用 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]