天然金雀花碱及其衍生物的化学结构和药理作用研究进展  

Research progress on chemical structures and pharmacological effects of natural cytisine and its derivatives

作　　者：周青青 谢晓艳 张燕霞 周武 占扎君 徐金标 ZHOU Qing-qing;XIE Xiao-yan;ZHANG Yan-xia;ZHOU Wu;ZHAN Zha-jun;XU Jin-biao(College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou 310014,China;College of Medicine,Jiaxing University,Jiaxing 314001,China)

机构地区：[1]浙江工业大学药学院,浙江杭州310014 [2]嘉兴学院医学院,浙江嘉兴314001

出　　处：《中国中药杂志》2023年第10期2679-2698,共20页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(82003612);创新嘉兴优才支持计划(202106)。

摘　　要：金雀花碱衍生物是指具有金雀花碱母核的一类生物碱,其主要存在于豆科植物中,具有广泛的生理活性,如抗炎、抗肿瘤、抗病毒和影响中枢神经系统等。目前,天然金雀花碱及其衍生物共报道了193个,它们都来源于L-赖氨酸。该文将天然金雀花碱衍生物归纳为金雀花碱型、鹰爪豆碱型、albine型、狭叶碱型、camoensidine型、类金雀花碱型、苏苦西碱型和lupanacosmine型8种结构类型,并对各类型生物碱的化学结构、植物来源、生物合成及药理活性的研究概况进行了综述。Cytisine derivatives are a group of alkaloids containing the structural core of cytisine,which are mainly distributed in Fabaceae plants with a wide range of pharmacological activities,such as resisting inflammation,tumors,and viruses,and affecting the central nervous system.At present,a total of 193 natural cytisine and its derivatives have been reported,all of which are derived from L-lysine.In this study,natural cytisine derivatives were classified into eight types,namely cytisine type,sparteine type,albine type,angustifoline type,camoensidine type,cytisine-like type,tsukushinamine type,and lupanacosmine type.This study reviewed the research progress on the structures,plant sources,biosynthesis,and pharmacological activities of alkaloids of various types.

关 键 词：金雀花碱 金雀花碱衍生物 豆科 生物合成 抗肿瘤活性 戒烟 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]