中国部分地区免疫规划疫苗可预防疾病经济负担和生命质量调查  

The economic burden of and quality of life with vaccine-preventable diseases targeted by Expanded Program on Immunization vaccines in several areas of China:a retrospective survey

作　　者：王淼[1] 张肇南 史金晶 宋祎凡[1] 曹雷[1] 叶家楷[1] 李力 曹玲生[1] 余文周[1] Wang Miao;Zhang Zhaonan;Shi Jinjing;Song Yifan;Cao Lei;Ye Jiakai;Li Li;Cao Lingsheng;Yu Wenzhou(National Immunization Program,Chinese Center for Disease Control and Prevention,Bejing 100050,China)

机构地区：[1]中国疾病预防控制中心免疫规划中心,北京100050

出　　处：《中国疫苗和免疫》2023年第2期138-143,共6页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解中国部分地区免疫规划(Expanded Program on Immunization,EPI)疫苗可预防疾病的经济负担和发病期生命质量。方法在中国八个省份各级医院中选择2015-2017年发病的七种EPI疫苗可预防疾病病例开展医疗相关费用的回顾性调查,分析人均经济负担;利用欧洲五维度健康量表调查发病期间的健康效用值。结果本调查分别纳入百日咳、麻疹、风疹、流行性腮腺炎、流行性乙型脑炎(乙脑)、流行性脑脊髓膜炎(流脑)、甲型肝炎病例87例、324例、108例、684例、142例、32例、240例,人均总经济负担分别为11255.14元/例、7807.74元/例、3277.63元/例、3387.62元/例、36717.02元/例、73360.87元/例、16612.43元/例,人均直接与间接经济负担之比分别为2.36、1.86、1.32、1.19、2.55、2.00、1.79,发病期间的平均健康效用值分别为0.87、0.81、0.82、0.86、0.63、0.05、0.81。结论调查地区七种EPI疫苗可预防疾病中流脑和乙脑的经济负担较重且在发病期的生命质量较差。Objective To evaluate the economic burden and quality of life in the onset period of Expanded Program on Immunization(EPI)targeted vaccine-preventable diseases.Methods We obtained data on cases of seven EPI-targeted vaccine-preventable diseases from all levels of hospitals in eight provinces of China between 2015 and 2017,conducted a retrospective survey of medical costs,and calculated per capita economic burden.We used the European Quality of Life-5 Dimensions(EQ-5D)tool to estimate health utility values of the diseases during their onset.Results The study included 87,324,108,684,142,32,and 240 cases of pertussis,measles,rubella,mumps,Japanese encephalitis,meningococcal meningitis,and hepatitis A.Total economic burdens per case for the seven diseases were 11255.14,7807.74,3277.63,3387.62,36717.02,73360.87,and 16612.43 yuan,with direct-to-indirect cost ratios of 2.36,1.86,1.32,1.19,2.55,2.00,and 1.79.Health utility values for the seven diseases were 0.87,0.81,0.82,0.86,0.63,0.05,and 0.81.Conclusions Japanese encephalitis and meningococcal meningitis had the heaviest economic burdens and were associated with the worst quality of life among seven EPI-targeted vaccine-preventable diseases.

关 键 词：免疫规划 疫苗可预防疾病 经济负担 健康效用值 生命质量 

分 类 号：R186[医药卫生—流行病学] R05[医药卫生—公共卫生与预防医学]