2020年陕西省1-69岁人群乙型肝炎血清流行病学调查  

A hepatitis B sero-epidemiological survey among 1-69-year-olds in Shaanxi province,2020

作　　者：周天天 张丹 王锐泽 李鹂[1] 董媛媛 胡伟军[1] Zhou Tiantian;Zhang Dan;Wang Ruize;Li Li;Dong Yuanyuan;Hu Weijun(Shaanxi Provincial Center for Disease Control and Prevention,Xi'an 710054,Shaanxi,China)

机构地区：[1]陕西省疾病预防控制中心,陕西西安710054

出　　处：《中国疫苗和免疫》2023年第2期164-168,共5页Chinese Journal of Vaccines and Immunization

基　　金：中国肝炎防治基金会中国乙肝防控科研基金资助项目(YGFK20170034、20200050);陕西省科技厅一般项目-社会发展领域(2022SF-210)。

摘　　要：目的了解陕西省1-69岁人群乙型肝炎病毒(Hepatitis B virus,HBV)标志物流行率。方法采用多阶段随机抽样方法,选取陕西省3个县1-69岁人群开展问卷调查和采集血清标本,检测血清乙肝表面抗原(Hepatitis B surface antigen,HBsAg)、表面抗体(Hepatitis B surface antibody,HBsAb)、e抗原(Hepatitis B e antigen,HBeAg)、e抗体(Hepatitis B e antibody,HBeAb)和核心抗体(Hepatitis B core antibody,HBcAb),分析HBV标志物阳性率、HBV感染率和标志物组合模式。结果共纳入调查对象1644例,HBsAg、HBsAb、HBeAg、HBeAb、HBcAb阳性率分别为1.82%、59.61%、0.24%、4.68%、24.88%(标化率:2.25%、56.87%、0.26%、5.74%、32.35%),HBV感染率为31.14%(标化率:38.40%)。1-4岁、5-14岁、15-29岁、30-69岁人群HBsAg阳性率分别为0.44%、0.32%、1.54%、2.95%,HBsAb阳性率分别为82.38%、58.28%、55.25%、55.33%,HBV感染率分别为6.17%、5.41%、27.16%、50.45%。共检出11种标志物组合模式,其中HBsAg+HBeAb+HBcAb阳性、HBsAg+HBeAg+HBcAb阳性分别占总调查人数的1.34%、0.24%。结论陕西省1-69岁人群特别是儿童HBsAg阳性率和HBV感染率进一步下降;需继续巩固儿童HepB常规免疫和HBV母婴传播阻断措施,开展重点成人的乙肝免疫预防。Objective To determine the seroprevalence of hepatitis B virus(HBV)markers among people 1-69 years of age in Shaanxi province.Methods We used a multi-stage random sampling method to select 1-69-year-olds in three counties of Shaanxi for a questionnaire-based survey and serum sample collection.We tested sera for hepatitis B surface antigen(HBsAg),surface antibody(HBsAb),e antigen(HBeAg),e antibody(HBeAb),and core antibody(HBcAb)to determine positivity rates of HBV markers,HBV infection rates,and HBV marker combination patterns.Results Among the 1644 subjects,HBsAg,HBsAb,HBeAg,HBeAb,and HBcAb positivity rates were 1.82%,59.61%,0.24%,4.68%,and 24.88%,respectively(adjusted:2.25%,56.87%,0.26%,5.74%,and 32.35%)with an HBV infection rate of 31.14%(adjusted:38.40%).Among 1-4-,5-14-,15-29-,and 30-69-year-olds,HBsAg positivity rates were 0.44%,0.32%,1.54%,and 2.95%;HBsAb positivity rates were 82.38%,58.28%,55.25%,and 55.33%;HBV infection rates were 6.17%,5.41%,27.16%,and 50.45%.Eleven marker combination patterns were detected,among which HBsAg+HBeAb+HBcAb positivity and HBsAg+HBeAg+HBcAb positivity accounted for 1.34%and 0.24%of subjects.Conclusions HBsAg carriage and HBV infection rates continued to decline among 1-69-year-old people in Shaanxi,especially ly among children.We should further strengthen routine childhood hepatitis B vaccination and other measures to interrupt mother-to-child HBV transmission and conduct hepatitis B immunoprophylaxis for certain adults.

关 键 词：乙型肝炎 乙型肝炎病毒 血清标志物 血清流行率 乙型肝炎疫苗 

分 类 号：R512.62[医药卫生—内科学]