The SARS-CoV-2 main protease induces neurotoxic TDP-43 cleavage and aggregates  

作　　者：Jiaxin Yang Yan Li Shijin Wang Huili Li Lili Zhang Haichen Zhang Pei-Hui Wang Xiangyu Zheng Xiao-Fang Yu Wei Wei 

机构地区：[1]Institute of Virology and AIDS Research,First Hospital,Jilin University,Changchun,Jilin 130021,China [2]Department of Neurology and Neuroscience Center,First Hospital,Jilin University,Changchun,Jilin 130021,China [3]Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute,Cheeloo College of Medicine,Shandong University,Jinan,China [4]Cancer Institute(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education),The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang,China [5]Cancer Center,Zhejiang University,Hangzhou,Zhejiang,China [6]Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education,Institute of Translational Medicine,First Hospital,Jilin University,Changchun,Jilin 130021,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第4期1364-1367,共4页信号转导与靶向治疗（英文）

摘　　要：Dear Editor,Neurologic manifestations associated with many COVID-19 patients,including acute infection with severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)and long COVID,have been proven by increasing evidence.1 To date,most studies have focused on how SARS-CoV-2 invades the nervous system and the consequent neuropathological changes.2,3 In contrast,the specific mechanism by which SARS-CoV-2 infection leads to neurological disease remains unclear.

关 键 词：ACUTE INFECTION RESPIRATORY 

分 类 号：R563.1[医药卫生—呼吸系统]