Structural characteristics of the SARS-CoV-2 Omicron lineages BA.1 and BA.2 virions  

作　　者：Xiaoyu Ma Yanqun Wang Yuanzhu Gao Yiliang Wang An Yan Jiantao Chen Lu Zhang Peiyi Wang Jincun Zhao Zheng Liu 

机构地区：[1]Cryo-electron Microscopy Center,Southern University of Science and Technology,Shenzhen,Guangdong,China [2]State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong,China [3]Health and Quarantine Laboratory,Guangzhou Customs District Technology Centre,Guangzhou,China [4]Guangzhou Laboratory,Bio-Island,Guangzhou,China [5]Institute of Infectious disease,Guangzhou Eighth People’s Hospital of Guangzhou Medical University,Guangzhou,Guangdong,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第4期1381-1383,共3页信号转导与靶向治疗（英文）

基　　金：the Cryo-electron Microscopy Center,Southern University of Science and Technology,for their assistance with data collection.This work was supported by the National Natural Science Foundation of China(82070329 to Z.L.,82172240 to Y.W.,82025001 to J.Z.).

摘　　要：Dear Editor,Variants of concern(VOCs)of SARS-CoV-2 have increased transmissibility,virulence,and resistance.The emergence of new VOCs continues to pose great challenges to public health.The detailed structures of the intact Omicron viruses remain unveiled.In this study,we report the architecture of both Omicron BA.1 and BA.2 lineages using cryo-electron tomography(cryo-ET).The subtomogram averaging of viral spikes,in both pre-fusion and postfusion conformations are also investigated.

关 键 词：characteristics OMI resistance. 

分 类 号：R373[医药卫生—病原生物学]