常规磁共振成像联合DWI及PWI预测多形性黄色星形细胞瘤的BRAF V600E基因的突变状态  

Prediction of BRAF V600E Mutational Status in Pleomorphic Xanthoastrocytoma Using Conventional Magnetic Resonance Imaging Combined with DWI and PWI

作　　者：康雅清 柯艺龙 杨谢锋 李坚[1] KANG Yaqing;KE Yilong;YANG Xiefeng(Department of Radiology,The First Affiliated Hospital of Fujian Medical University,Fuzhou,Fujian Province 350005,P.R.China)

机构地区：[1]福建医科大学附属第一医院影像科,福州350005

出　　处：《临床放射学杂志》2023年第4期538-543,共6页Journal of Clinical Radiology

摘　　要：目的探讨常规磁共振成像(MRI)、扩散加权成像(DWI)及灌注加权成像(PWI)特征对多形性黄色星形细胞瘤(PXA)的BRAF V600E基因的突变状态的诊断价值。方法回顾性分析经手术及病理证实的10例WHO 2级PXA及14例WHO 3级PXA的MRI、DWI及PWI资料,WHO 2级PXA中BRAF V600E突变型5例,野生型5例,WHO 3级PXA中BRAF V600E突变型8例,野生型6例,分别比较WHO 2级PXA及WHO 3级PXA突变型及野生型组间的常规MRI特点、最小ADC值(ADC_(min))、相对ADC_(min)(rADC_(min))及相对最大脑血容量(rCBV_(max))。结果WHO 2级PXA BRAF V600E野生组比突变组具有更大的病灶直径,更明显的瘤周水肿,更低的ADC_(min)、rADC_(min)及更大的rCBV_(max)(P<0.05)。结论常规MRI、DWI及PWI有助于预测2级PXA的BRAF V600E基因的突变状态。Objective To investigate the diagnostic value of conventional magnetic resonance imaging,diffusion⁃weigh⁃ted imaging(DWI)and perfusion⁃weighted imaging(PWI)features in predicting BRAF V600E mutational status in pleo⁃morphic xanthoastrocytoma(PXA).Methods MRI,DWI and PWI data of 10 cases of PXA(WHO grade 2)and 14 cases of PXA(WHO grade 3)with surgically and pathologically confirmed were retrospectively analyzed,including 5 cases of BRAF V600E mutant PXA(WHO grade 2),5 cases of wild type PXA(WHO grade 2),8 cases of BRAF V600E mutant PXA(WHO grade 3),and 6 cases of wild type PXA(WHO grade 3),The conventional MRI characteristics,ADC value(ADC_(min)),relative ADC_(min)(rADC_(min))and relative CBV_(max)(rCBV_(max))were compared between the two groups in PXA(WHO grade 2)and PXA(HO Grade 3),respectively.Results The PXA(WHO grade 2)BRAF V600E wild group had larger lesion diameter,more obvious peritumoral edema,lower ADC_(min),rADC_(min)and larger rCBV_(max)than the mutant group(P<0.05).Conclusion Conventional magnetic resonance imaging,DWI and PWI is useful for predicting BRAF V600E mutations of WHO grade 2PXA.

关 键 词：多形性黄色星形细胞瘤 BRAF V600E 突变 磁共振成像 扩散加权成像 灌注加权成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R739.4[医药卫生—诊断学]