山桃仁中2个新化合物的分离与鉴定  

Isolation and identification of two new compounds from Semen Persicae

作　　者：李恺之 杨书平 卢波涛 朱跃通 刘双晶 冯卫生[1,2] 王彦志 LI Kai-zhi;YANG Shu-ping;LU Bo-tao;ZHU Yue-tong;LIU Shuang-jing;FENG Wei-sheng;WANG Yan-zhi(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;Co-construction of Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan and Education Ministry of P.R.China,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院,河南郑州450046 [2]呼吸疾病中医药防治省部共建协同创新中心,河南郑州450046

出　　处：《药学学报》2023年第5期1288-1292,共5页Acta Pharmaceutica Sinica

摘　　要：运用ODS、Sephadex LH-20柱色谱,结合HPLC、半制备高效液相色谱方法从山桃仁乙酸乙酯部位中分离得到5个化合物。结合1D-NMR、2D-NMR、HR-ESI-MS、UV、IR、圆二色谱(CD)和计算ECD等方法,鉴定其分别为(2R,3R)-5,7,4′-trihydroxy-3′-methoxy-3-formylflavan-3-ol-5-O-β-D-glucopyranoside(1)、(7R,8S)-dihydrodehydrodiconiferyl 6″-benzoyl alcohol-9-O-β-D-glucopyranoside(2)、(7R,8S)-dihydrodehydrodiconiferyl alcohol-9-O-β-D-glucopyranosid(3)、2-methoxy-4-(2-propenyl)-phenyl-O-β-D-glucopyranoside(4)、2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propane-1,3-diol(5)。其中,化合物1和2为新化合物,化合物3~5为首次从该植物中分离得到。Five compounds were isolated from the ethyl acetate fraction of Semen Persicae by using various chromatographic methods,including ODS,Sephadex LH-20,HPLC and semipreparative HPLC.Their structures were identified by 1D-NMR,2D-NMR,HR-ESI-MS,UV,IR,circular dichroism(CD)and ECD calculation techniques:(2R,3R)-5,7,4′-trihydroxy-3′-methoxy-3-formylflavan-3-ol-5-O-β-D-glucopyranoside(1),(7R,8S)-dihydrodehydrodiconiferyl 6″-benzoyl alcohol-9-O-β-D-glucopyranoside(2),(7R,8S)-dihydrodehydrodiconiferyl alcohol-9-β-O-D-glucopyranosid(3),2-methoxy-4-(2-propenyl)-phenyl-O-β-D-glucopyranoside(4),2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propane-1,3-diol(5).Compound 1 and 2 are new compounds,and compounds 3-5 were obtained from Prunus davidiana(Carr.)Franch.for the first time.

关 键 词：蔷薇科 山桃仁 化学成分 黄酮苷 木脂素苷 

分 类 号：R284[医药卫生—中药学]