西咪替丁与双嘧达莫片联合治疗小儿过敏性紫癜的临床疗效及安全性分析  

Clinical Efficacy and Safety Analysis of Combination of Cimetidine and Dipyridamole Tablets in the Treatment of Pediatric Henoch-schonlein Purpura

作　　者：王小严 WANG Xiaoyan(Department of Pediatrics,Pizhou People's Hospital,Pizhou,Jiangsu Province,221300 China)

机构地区：[1]邳州市人民医院儿科,江苏邳州221300

出　　处：《中外医疗》2023年第13期129-132,141,共5页China & Foreign Medical Treatment

摘　　要：目的分析予以过敏性紫癜(henoch-schonlein purpura,HSP)患儿西咪替丁+双嘧达莫片治疗的临床效果。方法随机选择2021年1月—2022年8月在邳州市人民医院接受治疗的80例小儿HSP患儿为研究对象,以随机数表法分为对照组(40例,西咪替丁治疗),观察组(40例,西咪替丁+双嘧达莫片治疗)。对比两组疗效、症状消失时间、炎症指标、免疫指标及不良反应。结果观察组治疗有效率为95.00%,较对照组的77.50%更高,差异有统计学意义(χ^(2)=5.165,P<0.05)。观察组关节肿痛、紫癜、胃肠道症状消失时间为(2.81±0.92)、(12.02±2.15)、(2.97±0.41)d,均短于对照组的(5.81±1.25)、(14.53±3.31)、(5.78±1.30)d,差异有统计学意义(t=12.225、4.022、13.038,P<0.05)。治疗后,观察组TNF-α、IL-6、IL-10水平均低于对照组,差异有统计学意义(P<0.05);且观察组IgA、血清补体C3低于对照组,IgM、IgG高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率分别为7.50%、10.00%,差异无统计学意义(χ^(2)=0.000,P>0.05)。结论予以HSP患儿西咪替丁+双嘧达莫片治疗效果显著,可加快患儿症状消失时间,改善患儿炎症水平及免疫水平,且不良反应少。Objective To analyze the clinical effect of cimetidine+dipyridamole tablets treatment for children with henochschonlein purpura(HSP).Methods Eighty cases of pediatric HSP children treated in Pizhou People's Hospital from January 2021 to August 2022 were randomly selected for the study and divided into a control group(40 cases treated with cimetidine)and an observation group(40 cases treated with cimetidine+dipyridamole tablets)by the random number table method.The efficacy,symptom disappearance time,inflammation index,immune index and adverse reactions of the two groups were compared.Results The treatment efficiency of the observation group was 95.00%,which was higher than 77.50%of the control group,and the difference was statistically significant(χ^(2)=5.165,P<0.05).The disappearance time of arthralgias,purpura and gastrointestinal symptoms in the observation group was(2.81±0.92)d,(12.02±2.15)d,(2.97±0.41)d,which were shorter than(5.81±1.25)d,(14.53±3.31)d,(5.78±1.30)d in the control group,and the difference was statistically significant(t=12.225,4.022,13.038,P<0.05).After treatment,TNFα,IL6 and IL10 levels in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).And the IgA and serum complement C3 in the observation group were lower than those in the control group,and IgM and IgG were higher than those in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the two groups was 7.50%and 10.00%,respectively,and the difference was not statistically significant(χ^(2)=0.000,P>0.05).Conclusion Cimetidine+dipyridamole tablets were effective in treating children with HSP,accelerating the disappearance time of symptoms and improving the inflammation level and immune level of children with few adverse reactions.

关 键 词：小儿过敏性紫癜 西咪替丁 双嘧达莫片 炎症指标 免疫指标 

分 类 号：R725[医药卫生—儿科]