房颤导管消融(射频/冷冻)及药物治疗心房纤颤患者的相关临床研究  

Clinical Studies Related to Catheter Ablation of Atrial Fibrillation(Radiofrequency/Freezing)and Pharmacological Treatment of Patients with Atrial Fibrillation

作　　者：张勇 游卫华 李昌 葛辉梅 魏慧文 ZHANG Yong;YOU Wei-hua;LI Chang(Department of Cardiology,Maoming Petrochemical Hospital Affiliated to Guangdong Medical University,Maoming,Guangdong,525000,China)

机构地区：[1]广东医科大学附属茂名石化医院心内科,广东茂名525000

出　　处：《黑龙江医学》2023年第12期1431-1433,共3页Heilongjiang Medical Journal

基　　金：茂名市科技计划项目(210419174550162)。

摘　　要：目的:探讨房颤导管消融(射频/冷冻)及药物治疗心房纤颤患者的效果及对相关指标的影响。方法:选取2019年6月—2020年6月广东医科大学附属茂名石化医院心内科收治的100例心房纤颤患者作为研究对象,按照治疗方法不同分为对照组和观察组,每组各50例。对照组实施药物保守治疗,观察组实施导管消融手术治疗,对比两组患者心房纤颤发生率、血浆中脑钠肽浓度及治疗6个月、12个月的窦性心律维持率。结果:观察组心房纤颤发生率为4.0%,显著低于对照组的22.0%,差异有统计学意义(χ^(2)=3.259,P<0.05)。观察组血浆中脑钠肽浓度为(99.86±13.58)pg/mL,显著低于对照组的(659.46±50.84)pg/mL,差异有统计学意义(t=15.667,P<0.05)。观察组6个月、12个月时的窦性心律维持率均显著高于对照组,差异有统计学意义(χ^(2)=4.513、3.551,P<0.05)。结论:针对房颤患者,采用导管消融(射频/冷冻)与药物保守治疗相比,能够获得更好的治疗效果。Objective:To investigate the effect of catheter ablation of atrial fibrillation(radiofrequency/cryoablation)and drug treatment in patients with atrial fibrillation and the effect on related indexes.Methods:100 patients with atrial fibrillation admitted to the hospital from June 2019 to June 2020 were selected as study subjects and divided into control and observation groups according to different treatment methods,with 50 cases in each group.The control group was treated conservatively with drugs and the observation group was treated with catheter ablation procedure.The incidence of atrial fibrillation,the concentration of brain natriuretic peptide in plasma and the maintenance rate of sinus rhythm at 6 and 12 months of treatment were compared between the two groups.Results:The incidence of atrial fibrillation was 4.0%in the observation group,which was significantly lower than that of 22.0%in the control group,and the difference was statistically significant(χ^(2)=3.259,P<0.05).The plasma concentration of brain natriuretic peptide in the observation group was(99.86±13.58)pg/mL,which was significantly lower than(659.46±50.84)pg/mL in the control group,and the difference was statistically significant(t=15.667,P<0.05).The maintenance rate of sinus rhythm in the observation group at 6 and 12 months was significantly higher than that in the control group,and the difference was statistically significant(χ^(2)=4.513,3.551,P<0.05).Conclusion:The use of catheter ablation(radiofrequency/freezing)for patients with atrial fibrillation provides a better outcome compared to conservative drug therapy.

关 键 词：房颤 导管消融 射频 冷冻 药物治疗 临床研究 

分 类 号：R541.75[医药卫生—心血管疾病]