花椒属植物中酰胺类成分的结构与功能研究进展  

Research advance on structure and function of amides in Zanthoxylum plants

作　　者：叶倩女 石晓峰 杨军丽[3] YE Qian-nv;SHI Xiao-feng;YANG Jun-li(College of Pharmacy,Gansu University of Chinese Medicine,Lanzhou 730000,China;Institute of Materia Medica,Gansu Provincial Academic Institute for Medical Research,Lanzhou 730000,China;Key Laboratory of Chemistry of Northwestern Plant Resources,CAS,Key Laboratory for Natural Medicines of Gansu Province,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学药学院,甘肃兰州730000 [2]甘肃省医学科学研究院药物研究所,甘肃兰州730000 [3]中国科学院兰州化学物理研究所、中国科学院西北特色植物资源化学重点实验室、甘肃省天然药物重点实验室,甘肃兰州730000

出　　处：《中国中药杂志》2023年第9期2406-2418,共13页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金国际合作项目(32161143019)。

摘　　要：花椒属Zanthoxylum为芸香科Rutaceae植物,在我国有81种36变种。花椒属植物大多作为调味料,近年来国内外学者对其研究颇为深入,研究结果表明花椒属植物所特有的麻味来源于酰胺类化学成分,也确定酰胺类成分是发挥药理作用的重要物质基础,尤其在抗炎镇痛、麻醉等方面具有良好的效果。该文系统归纳了26种花椒属植物中已报道的123个酰胺类化学成分及其药理作用,为花椒属植物的临床应用、新药研发提供科学参考,也为其资源的可持续利用提供科学依据。Zanthoxylum belongs to the Rutaceae family,and there are 81 Zanthoxylum species and 36 varieties in China.Most of the Zanthoxylum plants are used as culinary spice.In recent years,scholars in China and abroad have carried out in-depth research on Zanthoxylum plants,and found that the peculiar numbing sensation of Zanthoxylum plants originates from amides.It is also determined that amides are an important material basis for exerting pharmacological effects,especially in anti-inflammatory analgesia,anesthesia and other aspects.In this paper,123 amides in 26 Zanthoxylum plants and their pharmacological activity that have been reported were summarized,which provided scientific reference for the clinical application of Zanthoxylum plants and the research and development of new drugs,and also facilitated the sustainable development and utilization of Zanthoxylum plant resources.

关 键 词：花椒属 酰胺类成分 分子结构 药理活性 

分 类 号：R284.1[医药卫生—中药学]