高胆红素血症新生儿肠道菌群特点与苯巴比妥治疗效果的相关性  

Correlation between Intestinal Microbiota Characteristics and The Effect of Phenobarbital Treatment in Newborns with Hyperbilirubinemia

作　　者：费英山[1] 卫雪利[2] 杨磊[1] 马桂霞 蔡磊[1] FEI Ying-shan;WEI Xue-li;YANG Lei;MA Gui-xia;CAI Lei(Department of Neonatology;Department of Paediatrics,General Hospital of Ningxia Medical University,Yinchuan,Ningxia,750004,China)

机构地区：[1]宁夏医科大学总医院新生儿科,宁夏银川750004 [2]宁夏医科大学总医院儿科,宁夏银川750004

出　　处：《现代生物医学进展》2023年第10期1911-1914,共4页Progress in Modern Biomedicine

基　　金：宁夏回族自治区自然科学基金项目(2020AAC03373)。

摘　　要：目的:探讨与分析高胆红素血症新生儿肠道菌群特点与苯巴比妥治疗效果的相关性。方法:选择2020年6月到2022年6月在本院诊治的565例高胆红素血症新生儿作为研究对象,所有患儿都给予苯巴比妥治疗,检测新生儿肠道菌群与血清α-谷胱甘肽-s-转移酶(α-GST)、肌酸激酶同工酶(CK-MB)、胆红素含量,判定患儿的治疗效果并进行相关性分析。结果:565例患儿治疗7 d后,有效490例(有效组),有效率为86.7%。有效组的血清胆红素、经皮胆红素含量都明显低于无效组(P<0.05)。有效组的血清α-GST、CK-MB含量都明显低于无效组(P<0.05)。有效组的肠球菌属、埃希氏菌属、链球菌属相对丰度均低于无效组,拟杆菌属相对丰度明显高于无效组(P<0.05)。在565例患儿中,Spearsman分析显示苯巴比妥治疗效果有效与肠球菌属、埃希氏菌属、链球菌属、拟杆菌属相对丰度都呈现相关性(P<0.05)。结论:苯巴比妥治疗新生儿高胆红素血症的效果有待提高,通过胆红素、α-GST、CK-MB、肠道菌群检测能有效判定患儿的治疗效果,同时肠道菌群与治疗效果存在相关性。Objective:To explore and analyze the correlation of gut flora characteristics and the effect of phenobbilbital treatment in newborns with hyperbilirubinemia.Methods:From June 2020 to June 2022,A total of 565 neonates with hyperbilirubinemia who were diagnosed and treated in our hospital from were selected as the research subjects.All the cases were treated with phenobarbital,The neonatal intestinal flora were detected,and serum α-glutathione-s-transferase(α-GST),creatine kinase isoenzyme(CK-MB),bilirubin levels were detected,and were to determine the patient with cases'treatment effect and correlation analysis.Results:After 7 days of treatment in 565 neonatesn,there were 490 cases were effective(effective group),and the effective rate was 86.7%.The contents of serum bilirubin and transdermal bilirubin in the effective group were lower than those in the ineffective group(P<0.05).The serumα-GST and CK-MB levels in the effective group were lower than those in the ineffective group(P<0.05).The relative abundances of Enterococcus,Escherichia and Streptococcus in the effective group were higher in the ineffective group,and the relative abundance of Bacteroides was higher than that in the ineffective group(P<0.05).In the 565 neonates,Spearsman analysis showed that the treatment effect of phenobarbital treatment was correlated with the relative abundances of Enterococcus,Escherichia,Streptococcus and Bacteroides(P<0.05).Conclusion:The effect of phenobarbital in the treatment of neonatal hyperbilirubinemia needs to be improved.The detection of bilirubin,α-GST,CK-MB can effectively determine the treatment effect of children with intestinal flora,and there is a correlation between intestinal flora and the treatment effect.

关 键 词：苯巴比妥 新生儿 高胆红素血症 肠道菌群 

分 类 号：R722[医药卫生—儿科]