热休克蛋白70在RNA病毒感染中的作用机制研究进展  

Heat Shock Protein 7 in RNA Virus Infection

作　　者：杨咏祺 刘格 钟剑锋 闫然 朱钦昌 YANG Yongqi;LIU Ge;ZHONG Jianfeng;YAN Ran;ZHU Qinchang(School of Pharmaceutical Sciences,Shenzhen University,Shenzhen 518060,China;College of Pharmacy,Shenzhen Technology University,Shenzhen 518118,China)

机构地区：[1]深圳大学医学部药学院,深圳518060 [2]深圳技术大学药学院,深圳518118

出　　处：《病毒学报》2023年第3期847-861,共15页Chinese Journal of Virology

摘　　要：本文综述了近年来热休克蛋白70(Heat shock protein 70,Hsp70)各亚型在RNA病毒感染中的作用及机制研究进展,以期总结梳理可能规律并发掘潜在抗RNA病毒途径。通过Scifinder, PubMed及中国知网等数据库检索高相关度文献,对Hsp70在RNA病毒感染的作用及机制研究进行分析比较归纳及讨论。Hsp70在RNA病毒感染中的作用机制呈现两重性:作为促感染因子辅助病毒感染,或作为免疫因子协助宿主抵抗病毒感染。Hsp70是对抗致病RNA病毒的切入点之一,在RNA病毒感染预防治疗上具有发展潜力。This article reviewed the role and mechanisms of heat shock protein 70(Hsp70)isoforms in RNA virus infection,to summarize the possible trend and explore potential anti-RNA virus pathways.High-relevance literatures were searched from Scifinder,PubMed and CNKI databases,and then we analyzed,compared,generalized and discussed role and mechanisms of Hsp70 isoforms in RNA virus infection.The mechanisms of Hsp70 in RNA virus infection were dual:as a pro-infective factor to assist virus infection,or as an immune factor to assist the host resistant to virus infection.Hsp70 is one of the key points against pathogenic RNA viruses,and has potential development in the prevention and treatment of RNA virus infection.

关 键 词：热休克蛋白70 RNA病毒 感染 作用机制 

分 类 号：R373.9[医药卫生—病原生物学] Q939.4[医药卫生—基础医学]