电化学固定CO_(2)构建羧酸衍生物的研究进展  

Recent Progress in Electrochemical Fixation of CO_(2) to Construct Carboxylic Acid Derivatives

作　　者：潘永周 蒙秀金 王迎春[3] 何慕雪 Pan Yongzhou;Meng Xiujin;Wang Yingchun;He Muxue(Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health,School of Public Health,Guilin Medical University,Guilin,Guangxi 541199;State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources,School of Chemistry and Pharmaceutical Sciences,Guangxi Normal University,Guilin,Guangxi 541004;College of Chemistry and Chemical Engineering,Jishou University,Jishou,Hunan 416000)

机构地区：[1]桂林医学院公共卫生学院广西环境暴露组学与全生命周期健康重点实验室,广西桂林541199 [2]广西师范大学化学与药学学院省部共建药用资源化学与药物分子工程国家重点实验室,广西桂林541004 [3]吉首大学化学化工学院,湖南吉首416000

出　　处：《有机化学》2023年第4期1416-1434,共19页Chinese Journal of Organic Chemistry

基　　金：广西自然科学基金(Nos.2022GXNSFBA035489,2021GXNSFBA196041);中央引导地方科技发展资金项目(No.桂科ZY21195014);“武陵山地区民族药解析与创制湖南省工程实验室”开放课题(No.hgxy2101)资助项目。

摘　　要：CO_(2)由于其含量丰富、无毒和低成本等特性可作为有机合成中的重要C1源,因此,使用CO_(2)作为C1源合成高附加值的化合物具有重要的意义.本综述重点介绍了在电化学条件下使用CO_(2)作为亲电试剂参与有机化合物羧化反应的最新进展.主要介绍了非活化有机卤化物、不饱和烯烃化合物和一些特殊化合物的电化学羧化,并就使用和不使用牺牲阳极进行了详细分类,讨论了这些反应的反应机制,为今后此类反应在有机合成中的应用提供参考.CO2 is an important C1 source in organic synthesis due to its abundant,non-toxic and low-cost properties.Therefore,it is of great significance to use CO_(2) as a C1 source to synthesize compounds with high added value.This review focuses on the recent progress in the carboxylation of organic compounds using CO_(2) as an electrophile under electrochemical conditions.The electrochemical carboxylation of non-activated organic halides,unsaturated alkene compounds and some special compounds are mainly introduced.And the use of sacrificial anodes and non-sacrificial anodes is classified in detail.The reaction mechanisms of these reactions are also discussed.This review provides a reference for the application of such reactions in organic synthesis in the future.

关 键 词：二氧化碳 羧化 羧酸衍生物 电化学合成 

分 类 号：O621.38[理学—有机化学]