一种N-杂环卡宾催化合成氘代苯偶姻的方法  

A Method for the Synthesis of Deuterated Benzoins Catalyzed by N-Heterocyclic Carbene

作　　者：张心予 耿慧慧 张士磊 王卫[1] 陈晓蓓[1] Zhang Xinyu;Geng Huihui;Zhang Shilei;Wang Wei;Chen Xiaobei(Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism,Shanghai Key Laboratory of New Drug Design,and State Key Laboratory of Bioengineering Reactor,School of Pharmacy,East China University of Science&Technology,Shanghai 200237)

机构地区：[1]华东理工大学药学院、上海市细胞代谢光遗传学技术前沿科学研究基地、上海市新药设计重点实验室生物反应器工程国家重点实验室,上海200237

出　　处：《有机化学》2023年第4期1510-1516,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.22071053,22271206);上海市细胞代谢光遗传学技术前沿科学研究基地(上海市教育委员会,grant 2021 Sci&Tech 03-28);江苏省高校重点学科建设(PAPD)资助项目。

摘　　要：利用D2O作为氘源,在N-杂环卡宾的催化下,两分子醛发生苯偶姻缩合反应(benzoin condensation)得到酮基α-位氘代的苯偶姻产物.反应条件温和、操作简单,多种芳香醛底物都可以给出高氘代率的产物.An efficient method has been developed for the synthesis of deuterated benzoins from two molecules of aldehydes under the catalysis of N-heterocyclic carbene by using D2O as the deuterium source,providing the products with deuterium selectively incorporated at theα-position of ketone group.The method features simple operation and mild reaction conditions,and a variety of aromatic aldehyde substrates could afford products with high deuterium incorporation.

关 键 词：氘代 重水 苯偶姻缩合 N-杂环卡宾 有机催化 

分 类 号：O621.251[理学—有机化学]