地枫皮中一个新的单萜杂合苯丙素成分  

A New Monoterpene-Phenylpropanoid from Illicium difengpi

作　　者：宁德生[1] 符毓夏 李连春 邹芷琪 潘争红[1] Ning Desheng;Fu Yuxia;Li Lianchun;Zou Zhiqi;Pan;Zhenghong(Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization,Guangxi Institute of Botany,Guangxi Zhuang Autonomous Region and Chinese Academy Sciences,Guilin,Guangxi 541006;College of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200)

机构地区：[1]广西壮族自治区中国科学院广西植物研究所、广西植物功能物质与资源持续利用重点实验室,广西桂林541006 [2]广西中医药大学药学院,南宁530200

出　　处：《有机化学》2023年第4期1591-1595,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.31960091);广西创新驱动发展专项(No.桂科AA18118015);广西自然科学基金(No.2018GXNSFBA281094);桂林市创新平台和人才计划(No.20210102-3)资助项目。

摘　　要：采用多种柱色谱分离技术对地枫皮树皮进行深入的化学成分研究,从其二氯甲烷部位中分离得到4个化合物,并通过质谱(MS)、红外光谱(IR)、核磁共振光谱(NMR)等谱学技术和量子化学计算方法对其结构分别鉴定为地枫皮醇D(1)、(E)-3,4-亚甲二氧基苯丙烯醛(2)、二氢荜澄茄素(3)和pestalotiopyrone G(4).化合物1是一个罕见的由链状单萜与苯丙素通过C—C杂合的新化合物,为八角属植物中首个单萜杂合苯丙素类成分.化合物1显示出弱的抗炎活性.Four compounds were isolated from the dichloromethane extract of stem bark of Illicium difengpi by using various column chromatographic methods.Their structures were identified as difengpienol D(1),(E)-3,4-methylenedioxophenyl propenal(2),dihydrocubebin(3)and pestalotiopyrone G(4)respectively by mass spectrometry(MS),infrared spectroscopy(IR),nuclear magnetic resonance spectroscopy(NMR),etc.and quantum chemical calculation method.Compound 1 was an unusual new compound formed by acyclic monoterpenoid and phenylpropanoid through C-C chain,and was also the first monoterpene-phenylpropanoid isolated from the genus Illicium.It showed weak anti-inflammatory activity.

关 键 词：地枫皮 单萜杂合苯丙素 结构鉴定 绝对构型 

分 类 号：R284.1[医药卫生—中药学]