IL-8和MMP-2在非小细胞肺癌患者胸腔镜肺段切除术预后评估中的价值  

Roles of IL-8 and MMP-2 in the prognosis of non-small cell lung cancer patients after thoracoscopic segmentectomy

作　　者：杨忠信[1] 李晓宇 陈涛 曹文军 YANG Zhongxin;LI Xiaoyu;CHEN Tao;CAO Wenjun(Thoracic Surgery,the First Affiliated Hospital of Henan University,Kaifeng 475000,Henan,China)

机构地区：[1]河南大学第一附属医院胸外科,河南开封475000

出　　处：《检验医学》2023年第4期342-346,共5页Laboratory Medicine

基　　金：河南省高等学校重点科研项目(18A320026)。

摘　　要：目的探讨血清白细胞介素8(IL-8)、基质金属蛋白酶2(MMP-2)水平在非小细胞肺癌(NSCLC)患者胸腔镜肺段切除术预后评估中的价值。方法选取101例行胸腔镜肺段切除术的NSCLC患者。收集所有患者的一般资料,检测其术前血清IL-8和MMP-2水平。对所有患者随访3年,根据是否出现复发分为复发组和未复发组。采用二元Logistic回归分析评估影响NSCLC患者复发的危险因素。采用受试者工作特征(ROC)曲线评价IL-8、MMP-2判断NSCLC患者复发的效能。采用Kaplan-Meier生存曲线和Log-rankχ^(2)检验评估NSCLC患者的复发情况。结果复发组术前血清IL-8、MMP-2水平显著高于未复发组(P<0.05)。以IL-8和MMP-2的均值分别作为临界值,将所有患者分为高表达组和低表达组。二元Logistic回归分析结果显示,术前血清IL-8≥87.52 ng/L和MMP-2≥477.86 ng/mL均是NSCLC患者复发的危险因素[比值比(OR)值分别为24.50、23.56,95%可信区间(CI)分别为18.94~37.23、18.01~38.29]。ROC曲线分析结果显示,术前IL-8和MMP-2判断NSCLC患者复发的曲线下面积(AUC)分别为0.834、0.858。Kaplan-Meier生存曲线分析结果显示,IL-8高表达组和MMP-2高表达组累积复发率分别显著高于IL-8低表达组和MMP-2低表达组(P<0.001)。结论术前血清IL-8、MMP-2水平可作为评估NSCLC患者胸腔镜肺段切除术预后的生物标志物。Objective To investigate the roles of serum interleukin-8(IL-8)and matrix metalloproteinase-2(MMP-2)levels in predicting the prognosis of non-small cell lung cancer(NSCLC)patients undergoing thoracoscopic segmentectomy.Methods Totally,101 patients with NSCLC who underwent thoracoscopic segmentectomy were enrolled.The general data were collected.IL-8 and MMP-2 were determined.The patients were followed up for 3 years.According to whether the patients had recurrence,they were classified into recurrence group and non-recurrence group.Binary Logistic regression analysis was used to analyze the risk factors affecting recurrence.Receiver operating characteristic(ROC)curve was used to analyze the clinical value of preoperative serum IL-8 and MMP-2 levels in predicting the prognosis of patients.Kaplan-Meier survival curve and Log-rankχ^(2)analysis were used to analyze the recurrence rate of NSCLC patients.Results Compared with non-recurrence group,the preoperative serum IL-8 and MMP-2 levels were higher in recurrence group(P<0.05).The levels of IL-8 and MMP-2 were taken as cut-off values,and all the patients were classified into high expression group and low expression group.The results of binary Logistic regression analysis showed that preoperative serum IL-8≥87.52 ng/L and MMP-2≥477.86 ng/mL are independent risk factors that affected recurrence[odds ratios(OR)were 24.50 and 23.56,95%confidence intervals(CI)were 18.94-37.23 and 18.01-38.29].ROC curve results showed that the area under curve(AUC)of IL-8 predicting recurrence was 0.834,and the AUC of MMP-2 predicting recurrence was 0.858.The results of Kaplan-Meier survival curve analysis showed that compared with IL-8 low expression group or MMP-2 low expression group,IL-8 high expression group or MMP-2 high expression group had a higher cumulative recurrence rate(P<0.001).Conclusions The preoperative serum IL-8 and MMP-2 levels can be used as biological markers to evaluate the prognosis of patients with NSCLC after thoracoscopic segmentectomy.

关 键 词：白细胞介素8 基质金属蛋白酶2 胸腔镜肺段切除术 非小细胞肺癌 

分 类 号：R446.1[医药卫生—诊断学]