岭南火针配合药物治疗成人期特应性皮炎疗效观察  

Efficacy observation of Lingnan fire needling combined with medication for adult atopic dermatitis

作　　者：陈广贤 林国华[1] 王澍欣[1] 吴跃峰[1] 方雅靖 CHEN Guangxian;LIN Guohua;WANG Shuxin;WU Yuefeng;FANG Yajing(The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China)

机构地区：[1]广州中医药大学第一附属医院,广州510405

出　　处：《上海针灸杂志》2023年第6期634-638,共5页Shanghai Journal of Acupuncture and Moxibustion

基　　金：广东省中医药局科研项目(20211135)。

摘　　要：目的观察岭南火针配合氯雷他定片治疗成人特应性皮炎(atopic dermatitis,AD)的临床疗效。方法将114例AD成年患者随机分为治疗组和对照组,每组57例。治疗组采用岭南火针配合口服氯雷他定片治疗,对照组采用单纯口服氯雷他定片治疗。观察两组治疗前后血清白细胞介素-4(interleukin-4,IL-4)、免疫球蛋白E(immunoglobulin E,IgE)和干扰素-γ(interferon-γ,IFN-γ)的水平以及AD评分(scoring atopic dermatitis,SCORAD)、湿疹面积及严重度指数(eczema area and severity index,EASI)和皮肤病生活质量指数(dermatology life quality index,DLQI)的评分变化,并比较两组临床疗效及不良反应发生率。结果两组治疗后血清IL-4和IgE水平均较同组治疗前显著下降(P<0.05),IFN-γ水平均显著上升(P<0.05),SCORAD、EASI及DLQI评分显著降低(P<0.05)。治疗组治疗后血清IL-4、IgE和IFN-γ的水平以及SCORAD、EASI和DLQI的评分与对照组比较,差异均具有统计学意义(P<0.05)。治疗组总有效率为96.5%,明显高于对照组的84.2%(P<0.05)。两组治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论岭南火针配合氯雷他定片治疗成人期AD疗效确切,能改善患者血清炎症反应,降低疾病严重程度,提高患者免疫力和生活质量,且安全性较高。Objective To observe the clinical efficacy of Lingnan fire needling combined with Loratadine tablets in treating atopic dermatitis(AD)in adults.Method A total of 114 adult AD patients were randomized into a treatment group and a control group,with 57 cases in each group.The treatment group was intervened by Lingnan fire needling plus oral Loratadine tablets,and the control group only received oral administration of Loratadine tablets.Before and after treatment,the serum levels of interleukin-4(IL-4),immunoglobulin E(IgE),and interferon-γ(IFN-γ)were observed for both groups,as well as the changes in the scores of the scoring atopic dermatitis(SCORAD),eczema area and severity index(EASI),and dermatology life quality index(DLQI).Clinical efficacy and adverse reaction rate were also compared between the two groups.Result After treatment,there was a significant drop in the serum levels of IL-4 and IgE in both groups(P<0.05),and a significant increase was found in the level of IFN-γ(P<0.05),together with markedly reduced SCORAD,EASI,and DLQI scores(P<0.05).After treatment,the between-group differences in the serum levels of IL-4,IgE,and IFN-γand the scores of SCORAD,EASI,and DLQI were statistically significant(P<0.05).The total effective rate was 96.5%in the treatment group,notably higher than 84.2%in the control group(P<0.05).There was no significant difference in the adverse reaction rate between the two groups(P>0.05).Conclusion Lingnan fire needling combined with Loratadine is effective in treating adult AD;it can improve patients’serum inflammatory reactions,lower disease severity,and enhance immunity and quality of life with high safety.

关 键 词：火针疗法 皮炎 特应性 针药并用 白细胞介素-4 免疫球蛋白E 干扰素-γ 

分 类 号：R246.7[医药卫生—针灸推拿学]