QAS联合QIMT技术对正常高值血压患者颈动脉硬化的研究  

The study of QAS combined with QIMT technology on carotid atherosclerosis in patients with normal high blood pressure

作　　者：张文静[1] 温德惠[2] 郑英娟[2] 李朝喜[2] 牛亚军[2] 苗青 ZHANG Wenjing;WEN Dehui;ZHENG Yingjuan;LI Chaoxi;NIU Yajun;MIAO Qing(Hebei North University,Zhangjiakou 075000,China;Department of Ultrasound,the First Affiliated Hospital of Hebei North University)

机构地区：[1]河北北方学院,075000 [2]河北北方学院附属第一医院超声医学科

出　　处：《天津医药》2023年第6期662-667,共6页Tianjin Medical Journal

基　　金：张家口市科技发展计划项目(1911021D-4)。

摘　　要：目的应用动脉僵硬度定量检测(QAS)技术联合血管内-中膜分析(QIMT)技术评价正常高值血压患者颈动脉的结构与功能。方法根据血压水平将接受颈动脉超声及QAS联合QIMT检查的人群分为血压正常组(82例)、正常高值血压组(90例)和高血压组(68例)。应用QAS技术测量双侧颈动脉的弹性参数:扩张系数(DC),顺应性系数(CC),僵硬度系数(α、β),脉搏波传导速度(PWV);应用QIMT技术测量双侧颈动脉内-中膜厚度(IMT);收集受检者体质量指数(BMI)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)。比较各组不同性别间颈动脉各弹性参数及IMT,正常高值血压患者颈动脉左侧和右侧各弹性参数及不同水平血压各组颈动脉各弹性参数及IMT,分析血脂与各参数的相关性。结果正常高值血压组男性颈动脉IMT高于女性(P<0.05),左侧和右侧颈动脉IMT、DC、CC、α、β及PWV比较,差异均无统计学意义;与血压正常组相比,正常高值血压组与高血压组的IMT、α、β、PWV增大,DC、CC减小;高血压组PWV较正常高值血压组增大(P<0.05)。正常高值血压患者HDL-C与DC、CC呈正相关,与α、β、PWV呈负相关(P<0.01);LDL-C与DC、CC呈负相关,与α、β、PWV呈正相关(P<0.01)。结论应用QAS联合QIMT技术发现正常高值血压患者颈动脉弹性减低,IMT增厚。Objective To evaluate structure and function of carotid artery in patients with high-normal blood pressure by quality arterial stiffness(QAS)combined with quality intima media thickness(QIMT).Methods According to blood pressure levels,patients who underwent carotid ultrasound and QAS combined with QIMT were divided into the normal blood pressure group(n=82),the normal high-value blood pressure group(n=90)and the hypertension group(n=68).The elastic parameters of bilateral carotid artery were measured by QAS technique,including dilation coefficient(DC),compliance coefficient(CC),stiffness coefficient(α,β)and pulse wave conduction velocity(PWV).The internal media thickness(IMT)of bilateral carotid arteries was measured by QIMT technique.Body mass index(BMI),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)were collected.Carotid artery elastic parameters and IMT were compared between different gender groups.The left and right carotid artery elastic parameters in patients with normal high blood pressure and the carotid artery elastic parameters and IMT with different blood pressure levels were also compared in different groups.The correlation between blood lipid and each parameter was analyzed.Results The IMT of carotid artery was higher in men with normal high blood pressure than that in women(P<0.05).There were no significant differences in IMT,DC,CC,α,βand PWV between left and right carotid arteries.Compared with the normal blood pressure group,the IMT,α,βand PWV were increased in the normal high blood pressure group and the hypertension group,while DC and CC were decreased(P<0.05).HDL-C was positively correlated with DC and CC,but negatively correlated withα,βand PWV in the normal high-value blood pressure patients(P<0.01).LDL-C was negatively correlated with DC and CC,but positively correlated withα,βand PWV in the normal high-value blood pressure group(P<0.01).Conclusion QAS combined with QIMT shows that carotid artery elas

关 键 词：高血压 血管硬化程度 颈动脉内膜中膜厚度 正常高值血压 

分 类 号：R544.1[医药卫生—心血管疾病] R445.1[医药卫生—内科学]