In(OTf)_(3)催化双亚胺分子间环化反应合成吖啶  

In(OTf)_(3)-catalyzed Intermolecular[3+2+1]Cyclization of Two Imine Units

作　　者：南江 刘石磊 黄冠杰 NAN Jiang;LIU Shilei;HUANG Guanjie(Key Laboratory of Chemical Additives for China National Light Industry,College of Chemistry and Chemical Engineering,Shaanxi University of Science and Technology,Xi’an 710021,China)

机构地区：[1]陕西科技大学化学化工学院,中国轻工业轻化工助剂重点实验室,西安710021

出　　处：《高等学校化学学报》2023年第6期83-90,共8页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:22171171);陕西省青年科技新星项目(批准号:2022KJXX-15);陕西省科协人才托举项目(批准号:20200605)资助。

摘　　要：使用廉价易得的亚胺化合物在In(OTf)_(3)与氧化剂串联条件下进行[3+2+1]环化反应,实现了亚胺分子的新化学转化模式,最终以良好至优秀的产率合成了23种结构新颖的吖啶衍生物.该方法条件简单,具有良好的底物适用性与基团兼容性,为在光电材料领域广泛应用的吖啶化合物的合成提供了一种新途径.A facile In(OTf)_(3)-catalyzed[3+2+1]annulation reaction between imine units was developed,which represents a novel chemical transformation with imines.In this conversion,23 kinds of structurally diversified acridine derivatives were rapidly obtained in moderate to excellent yields.This protocol features broad substrate scope and excellent functional groups tolerance,giving a new platform for preparing acridines widely used in the program of photoelectric materials.

关 键 词：LEWIS酸催化 吖啶衍生物 亚胺环化 

分 类 号：O626[理学—有机化学]