内皮间质转分化在器官纤维化中的研究进展  

Research progress of endothelial-mesenchymal transdifferentiation in fibrotic diseases

作　　者：刘依 尹玉洁 李真 王亚芬 郝苑洁 贾振华[1,2,3,4,5,6] LIU Yi;YIN Yu-jie;LI Zhen;WANG Ya-fen;HAO Yuan-jie;JIA Zhen-hua(Graduate School,Hebei Medical University,Shijiazhuang 050017,China;Hebei Yiling Hospital,Shijiazhuang 050091,China;National Key Laboratory for Innovation and Transformation of Luobing Theory;Key Research Laboratory of National Administration of Traditional Chinese Medicine(Cardio-Cerebral Vessel Collateral Disease);Hebei Institute of Integrative Traditional Chinese and Western Medicine,Shijiazhuang 050035,China;Graduate School,Hebei University of Chinese Medicine,Shijiazhuang 050091,China)

机构地区：[1]河北医科大学研究生学院,河北石家庄050017 [2]河北以岭医院,河北石家庄050091 [3]络病理论创新转化全国重点实验室 [4]国家中医药管理局重点研究室(心脑血管络病) [5]河北省中西医结合医药研究院,河北石家庄050035 [6]河北中医学院研究生学院,河北石家庄050091

出　　处：《中国药理学通报》2023年第6期1014-1019,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81973692);国家重点研发计划资助项目(No 2017YFC1700500);河北省自然科学基金资助项目(No H2018106043)。

摘　　要：纤维化是各组织器官在受到损伤刺激后启动的修复反应,是机体的一种自我保护机制。研究发现,内皮间质转分化(endothelial-to-mesenchymal transition,EndMT)参与心脏、肺脏、肾脏、肝脏、胰腺等多种器官纤维化的生理病理过程,已成为纤维化疾病研究的一个重点。该文将总结EndMT的调控机制及其在器官纤维化中作用,以及以EndMT为靶点的相关治疗进展,以期为器官纤维化的防治提供新的靶点。Fibrosis is a repair response initiated by tissues and organs after injury,and is a self-protection mechanism of the body.It has been found that endothelium-to-interstitial transdifferentiation(EndMT)is involved in the physiological and pathological processes of various organ fibrosis,which has become a focus of the research on fibrotic diseases.In recent years,the study has found that EndMT plays an important role in many pathological processes in cardiovascular system,lungs,kidneys,liver,pancreas fibrosis,and so on.This article summarizes EndMT regulatory mechanism and its role in each organ fibrosis,as well as the related treatment progress of EndMT targets,so as to provide new targets for prevention and control of organ fibrosis.

关 键 词：内皮间质转分化 内皮细胞 TGF-Β信号通路 NOTCH信号通路 心肌纤维化 肺纤维化 肝纤维化 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学] R364.32[医药卫生—基础医学] R542.23R563.13R575.2