颈动脉斑块超声造影特征与急性脑梗死面积的关系  

The relationship between contrast-enhanced ultrasound characteristics of carotid plaque and the area of acute cerebral infarction

作　　者：方桂婷 井珍[2] 张华国 李金花[1] 赖晓敏 钟兴[1] FANG Guiting;JING Zhen;ZHANG Huaguo;LI Jinhua;LAI Xiaoming;ZHONG Xing(Department of Ultrasound,the First Affiliated Hospital,Jinan University,Guangzhou 510630,Guangdong,China;Department of Neurology,the First Affiliated Hospital,Jinan University,Guangzhou 510630,Guangdong,China)

机构地区：[1]暨南大学附属第一医院超声医学科,广东广州510630 [2]暨南大学附属第一医院神经内科,广东广州510630

出　　处：《暨南大学学报（自然科学与医学版）》2023年第2期165-170,共6页Journal of Jinan University(Natural Science & Medicine Edition)

摘　　要：目的:分析颈动脉斑块超声造影特征与急性脑梗死面积的关系。方法:收集就诊于暨南大学附属第一医院神经内科行颈动脉超声造影检查的患者80例,其中急性脑梗死患者56例(脑梗死组),无脑梗死患者24例(对照组)。根据急性脑梗死患者头颅磁共振成像(MRI)扩散加权成像序列(DWI)显示脑梗死面积大小,分为大面积脑梗死组24例,小面积脑梗死组32例,比较大、小面积脑梗死组和对照组3组间的颈动脉斑块的超声造影特征差异。结果:颈动脉斑块的超声造影半定量参数显示,大面积脑梗死组Ⅰ级占比为8.33%,Ⅱ级占比为25.00%,Ⅲ级占比为66.67%;小面积脑梗死组Ⅰ级占比为21.87%,Ⅱ级占比为40.63%,Ⅲ级占比为37.50%;对照组Ⅰ级占比为37.50%,Ⅱ级占比为41.67%,Ⅲ级占比为20.83%,3组间的差异有统计学意义(χ^(2)=11.44,P=0.01)。颈动脉斑块超声造影定量参数显示,大面积脑梗死组、小面积脑梗死组、对照组3组间的增强强度(EI)的差异有统计学意义(F=7.01,P=0.01)。其中大面积脑梗死组的EI(4.23±3.06)高于小面积脑梗死组(2.87±1.81)及对照组(1.95±1.17),组间差异均有统计学意义(P=0.01)。3组间的峰值强度(PI)值差异有统计学意义(F=5.84,P=0.01),其中大面积脑梗死组为(5.69±2.71)高于小面积脑梗死组(3.97±2.48),差异有统计学意义(P=0.01);小面积脑梗死组(3.97±2.48)高于对照组(3.53±1.63),但差异无统计学意义(P>0.05)。结论:颈动脉斑块超声造影半定量分级及定量参数与急性脑梗死的发生及梗死面积有关,颈动脉斑块造影有助于预测急性脑梗死的发生和判断预后。Objective:The relationship between carotid plaque's characteristics of contrast-enhanced ultrasound and the area of acute cerebral infarction was investigated.Methods:A total of 80 patients who underwent contrast-enhanced carotid artery ultrasound at the department of neurology of the First Affiliated Hospital of Jinan University were collected,among which 56 patients with acute cerebral infarction and 24 patients without cerebral infarction were divided into the cerebral infarction group and the control group,respectively.While in the cerebral infarction group,patients with acute cerebral infarction were further divided into the large area cerebral infarction group(24 cases)and small area cerebral infarction group(32 cases)in accordance with the size of acute cerebral infarction in the diffusion weighted imaging(DWI)sequence of magnetic resonance image(MRI).The features of contrast-enhanced ultrasound of carotid plaques were compared among the large area cerebral infarction group,small area cerebral infarction group and the control group.Results:The semi-quantitative parameters of contrast-enhanced ultrasound of carotid plaque demonstrated that the patients with GradeⅠ,GradeⅡand GradeⅢwas accounted for 8.33%,25.00%and 66.67%in large area cerebral infarction group,respectively.The patients with GradeⅠ,GradeⅡand GradeⅢwas accounted for 21.87%,40.63%,and 37.50%in the small area cerebral infarction group,respectively.The patients with GradeⅠ,GradeⅡand GradeⅢwas accounted for 37.50%,41.67%and 20.83%in the control group,respectively.There are significant differences among the three groups(χ^(2)=11.44,P=0.01).As for the quantitative parameters of contrast-enhanced ultrasound of carotid plaque,the Enhanced Intensity(EI)(4.23±3.06)of the large area cerebral infarction group was substantially higher than EI(2.87±1.81)in the small area cerebral infarction group and EI(1.95±1.17)of the control group,which demonstrated the significant differences(F=7.01,P=0.01).Among three groups,EI was significant diff

关 键 词：颈动脉斑块 脑梗死 超声造影 定量分析 

分 类 号：R445.1[医药卫生—影像医学与核医学]