纳布啡预处理减轻无痛胃镜检查患者丙泊酚注射痛的半数有效量  

Nalbuphine preconditioning reduces half of the effective dose of propofol injection pain in painless gastroscopy patients

作　　者：杜宁 张如意[1] 夏艳萍[1] 陈琳 张全意[1] DU Ning;ZHANG Ruyi;XIA Yanping;CHEN Lin;ZHANG Quanyi(Department of Anesthesiology,Affiliated Hospital of Binzhou Medical Col lege,Binzhou Shandong 256600)

机构地区：[1]滨州医学院附属医院麻醉科,山东滨州256600

出　　处：《当代医药论丛》2023年第11期117-120,共4页

基　　金：项目名称:山东省省级临床重点专科学科建设项目(编号:SLCZDZK-20)。

摘　　要：目的:探讨纳布啡预处理减轻无痛胃镜检查患者丙泊酚注射痛的半数有效量。方法:选取2021年9月至12月在滨州医学院附属医院行无痛胃镜检查的患者,年龄20~50岁,ASA分级Ⅰ~Ⅱ级。试验采用的方法为改良序贯法,即第1例患者给予纳布啡0.1 mg/kg注射后,再静脉注射丙泊酚2.0 mg/kg,两次注射相隔5 min。采用Ambesh 4分法评价丙泊酚注射痛,如果患者发生注射痛,则下一例患者增加纳布啡剂量0.01 mg/kg,若未发生注射痛,则降低0.01 mg/kg。重复上述过程,直到出现第7个注射痛阳性转阴拐点后终止研究。采用Probit法计算半数有效量(ED50)及其95%置信区间(CI)。结果:纳布啡预防胃镜检查年轻患者丙泊酚注射痛的ED50为0.06 mg/kg(95%CI 0.020~0.078 mg/kg)。结论:纳布啡预处理减轻胃镜检查患者丙泊酚注射痛的半数有效量是0.06 mg/kg。Objective:To investigate the half effective dose of nalbuphine pretreatment to relieve pain of propofol injection in painless gastroscopy patients.Methods:Patients aged 20-50 years old who underwent painless gastroscopy in the Affiliated Hospital of Binzhou Medical College from September to December 2021 were selected,ASA grade Ⅰ toⅡ.The modified sequential method was used in the trial,i.e.,the first patient received 0.1 mg/kg injection of nalbuphine followed by 2.0 mg/kg intravenous injection of propofol,5 min apart.The Ambesh 4-point method was used to evaluate propofol injection pain.If injection pain occurred in the patient,the dose of nalbuphine was increased by 0.01 mg/kg in the next patient;if injection pain did not occur,the dose was decreased by 0.01 mg/kg.The above procedure was repeated until the study was terminated at the 7th negative turning point for injection pain.Half effective dose(ED50)and 95%confidence interval(CI)were calculated by Probit method.Results:The ED50 of Nalbuphine for propofol injection pain prevention was 0.06 mg/kg(95%CI 0.020-0.078 mg/kg)in young patients with gastroscopy.Conclusion:The half effective dose of nalbuphine pretreatment to relieve propofol injection pain in g astroscopy patients is 0.06 mg/kg.

关 键 词：纳布啡 无痛胃镜 注射痛 改良序贯法 半数有效量 

分 类 号：R614[医药卫生—麻醉学]