红桃消肿合剂对创伤性颅脑损伤患者血栓前状态及静脉血栓栓塞症防治效果的随机对照研究  

A randomized controlled study of Hongtao Xiaozhong Mixture on prethrombot ic status and prevention of venous thromboembolism in patients with traumatic craniocerebral injury

作　　者：杜丽娟 宋璐 王志刚 唐何军 DU Lijuan;SONG Lu;WANG Zhigang;TANG Hejun(Shenzhen Pingle Orthopedics Hospital,Shenzhen Pingshan Hospital of Trad itional Chinese Medicine,Shenzhen Guangdong 518000)

机构地区：[1]深圳平乐骨伤科医院,深圳市坪山区中医院,广东深圳518000

出　　处：《当代医药论丛》2023年第11期163-166,共4页

基　　金：广东省中医药局科研项目(项目编号:20211352)。

摘　　要：目的:探究用红桃消肿合剂对创伤性颅脑损伤患者进行血栓前状态及静脉血栓栓塞症防治的效果。方法:回顾性分析深圳平乐骨伤科医院2021年1月至2022年8月收治的60例创伤性颅脑损伤患者的临床资料,采用序贯法将其分为观察组和对照组。对照组(n=30)采用物理方法预防血栓前状态及静脉血栓栓塞症,观察组(n=30)在对照组基础上采用红桃消肿合剂进行干预。观察两组的干预效果、干预前后血细胞比容、红细胞聚集指数、毛细管血浆黏度、血栓前状态分子标志物水平〔D-二聚体、纤维蛋白原(FIB)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)〕、静脉血栓发生率及炎性因子水平〔白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)〕。结果:两组治疗前的血细胞比容、红细胞聚集指数、毛细管血浆黏度相比无显著差异(P>0.05)。治疗后,观察组的血细胞比容、红细胞聚集指数、毛细管血浆黏度均优于对照组(P<0.05)。治疗前,两组的D-二聚体、FIB、PT、APTT水平相比无显著差异(P>0.05)。治疗后,观察组的D-二聚体、FIB、PT、APTT水平均优于对照组(P<0.05)。治疗前,两组的IL-2、TNF-α水平相比无显著差异(P>0.05)。治疗后,观察组的IL-2、TNF-α水平均优于对照组(P<0.05)。观察组的静脉血栓发生率低于对照组,差异有统计学意义(P<0.05)。结论:用红桃消肿合剂对创伤性颅脑损伤患者进行血栓前状态及静脉血栓栓塞症防治的效果显著,可有效改善其凝血指标及炎性因子的水平,降低其静脉血栓的发生率。此法值得在临床上推广应用。Objective:To explore the effect of Hongtao Xiaozhong mixture on the prevention and treatment of prethrombotic state and venous thromboembolism in patients with traumatic craniocerebral injury.Methods:The clinical data of 60 patients with traumatic craniocerebral injury admitted to Shenzhen Pingle Orthopedics Hospital from January 2021 to August 2022 were retrospectively analyzed and divided into observation group and control group by sequential method.The control group(n=30)was treated with physical methods to prevent prethrombotic state and venous thromboembolism,and the observation group(n=30)was treated with Hongtao Xiaozhong mixture on the basis of the control group.The intervention effects,hemocytometer,erythrocyte aggregation index,capillary plasma viscosity,pre-thrombotic molecular markers(D-dimer,fibrinogen(FIB),prothrombin time(PT),activated partial thrombin time(APTT)),venous thrombosis incidence and inflammatory factor levels[interleukin-2(IL)before and after intervention were observed in the two groups-2,tumor necrosis factor-α(TNF-α)].Results:There were no significant differences in hematocrit,erythrocyte aggregation index and capillary plasma viscosity between the two groups before treatment(P>0.05).After treatment,the hematocrit,erythrocyte aggregation index and capillary plasma viscosity of observation group were better than those of control group(P<0.05).Before treatment,there were no significant differences in D-dimer,FIB,PT and APTT levels between the two groups(P>0.05).After treatment,the levels of D-dimer,FIB,PT and APTT in observation group were better than those in control group(P<0.05).Before treatment,there were no significant differences in IL-2 and TNF-αlevels between the two groups(P>0.05).After treatment,the levels of IL-2 and TNF-αin observation group were better than those in control group(P<0.05).The incidence of venous thrombosis in observation group was lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion:Hongtao Xiaotuo Mixture

关 键 词：红桃消肿合剂 创伤性颅脑损伤 静脉血栓栓塞症 物理预防 血栓前状态分子标志物 

分 类 号：R651.15[医药卫生—外科学]