蒙药额尔敦-乌日勒对老年患者胸科手术后睡眠质量的影响  

Effect of Eerdun Wurile on sleep quality of elderly patients after thoracic surgery

作　　者：张宇斌 澈力木格[1] 于建设[2] 刘桧[2] 苏恩博尔 都义日[2] ZHANG Yubin;CHE Limuge;YU Jianshe;LIU Hui;SU Enboer;DU Yiri(The First Clinical Medical College,Inner Mongolia Medical University,Hohhot 010000,China)

机构地区：[1]内蒙古医科大学第一临床医学院,呼和浩特市010000 [2]内蒙古医科大学附属医院麻醉科

出　　处：《临床麻醉学杂志》2023年第5期506-509,共4页Journal of Clinical Anesthesiology

基　　金：内蒙古自治区蒙医药协同创新中心科研项目(MYYXT201902);内蒙古自然科学基金(2020LH08032);内蒙古医科大学附属医院博士启动基金项目(NYFY BS202134);高等学校青年科技英才支持计划项目(NJYT22020)。

摘　　要：目的探讨蒙药额尔敦-乌日勒对老年患者胸科手术后睡眠质量的影响。方法选择择期行胸科手术的老年患者60例,男31例,女29例,年龄≥65岁,BMI 18~24 kg/m^(2),ASAⅠ—Ⅲ级。采用随机数字表法将患者分为两组:对照组(C组)和蒙药额尔敦-乌日勒组(E组),每组30例。C组于术前3 d至术后3 d每日晨起后口服淀粉胶囊;E组在相同时间点口服蒙药额尔敦-乌日勒15粒(每粒2 g)。采用匹兹堡睡眠质量指数量表(PSQI)评估术前3 d和术后1个月患者夜间睡眠质量。采用理查兹-坎贝尔睡眠量表(RCSQ)评估术前3 d和术后第1天夜间睡眠质量。采用ELISA法检测术前3 d服药前、术后第1、4天血浆褪黑素(MT)、γ-氨基丁酸(GABA)和肿瘤坏死因子-α(TNF-α)浓度。采用术后恢复质量量表(QoR-40)评估患者恢复质量。结果与C组比较,E组术后1个月PSQI量表评分明显降低,术后第1天RCSQ量表评分明显增高(P<0.05),术后第1、4天MT浓度和GABA浓度明显升高,TNF-α浓度明显降低(P<0.05),术后第1天情绪状态、身体舒适度、自理能力和总分明显升高(P<0.05)。结论围术期服用蒙药额尔敦-乌日勒有助于改善患者术后睡眠质量,促进患者术后快速康复。Objective To investigate the effect of Eerdun Wurile,a Mongolian drug,on sleep quality in elderly patients after thoracic surgery.Methods Sixty elderly patients undergoing elective thoracic surgery,31 males and 29 females,aged≥65 years,BMI 18-24 kg/m^(2),ASA physical statusⅠ-Ⅲ,were randomly divided into two groups:control group(group C)and Eerdun Wurile group(group E),30 patients in each group.In group C,starch capsules were taken orally every morning from 3 days before surgery to 3 days after surgery.Group E was treated with 15 tablets of Eerdun Wurile(2 g per capsule)at the same time.The patients sleep quality was assessed with the Pittsburgh sleep quality index(PSQI)3 days before surgery and 1 month after surgery.The Richards-Campbell sleep scale(RCSQ)was used to assess the quality of night sleep 3 days before surgery and 1st day after surgery.The plasma melatonin(MT),γ-aminobutyric acid(GABA)and tumor necrosis factor-α(TNF-α)concentrations before taking medicine 3 days before surgery,on the 1st day and 4th day after surgery were measured by ELISA.And the quality of postoperative recovery scale(QoR-40)was used to assess the quality of recovery.Results Compared with group C,PSQI score was significantly decreased in group E 1 month after surgery and RCSQ score was significantly increased on the 1st day after surgery(P<0.05).Compared with group C,the MT and GABA concentrations in group E were significantly increased on the 1st and 4th day after operation,and the TNF-αconcentration was significantly decreased on the 1st and 4th day after surgery(P<0.05).Compared with group C,the emotional state,physical comfort,self-care ability and total score of patients in group E were increased significantly on the 1st day after surgery(P<0.05).Conclusion Perioperative administration of Mongolian drug Eerdun Wurile improves the postoperative sleep quality and promote rapid recovery.

关 键 词：额尔敦-乌日勒 老年 胸科手术 术后睡眠质量 褪黑素 

分 类 号：R29[医药卫生—民族医学]