颅脑损伤患者血浆suPAR、凝血功能及血清钠离子水平与其病情、预后的关系  

Relationship between plasma suPAR,coagulation function and serum sodium ion level and their disease condition and prognosisin patients with craniocerebral injury

作　　者：孙思辉 杨安强[1] 贺杰 SUN Sihui;YANG Anqiang;HE Jie(Department of Neurosurgery,Yibin First People's Hospital,Yibin 644000,Sichuan,China)

机构地区：[1]宜宾市第一人民医院神经外科,四川宜宾644000

出　　处：《西部医学》2023年第6期885-888,共4页Medical Journal of West China

基　　金：四川省卫生计生委科研课题(18PJ535)。

摘　　要：目的探讨颅脑损伤患者血浆可溶性尿激酶型纤溶酶原激活物受体(suPAR)、凝血功能及血清钠离子水平与其病情、预后的关系。方法选取2018年5月—2021年5月本院收治的颅脑损伤患者116例行回顾性分析,并设为研究组,根据术前GCS评分研究组中重型(重型组)39例、中型(中型组)36例、轻型(轻型组)41例;选取同时间段进行健康体检者104例作为对照组。对比不同人群suPAR、APTT、PT、Fbg及钠离子水平,收集随访资料,分析颅脑损伤患者suPAR、APTT、PT、Fbg及钠离子水平与预后的相关性。结果研究组suPAR、APTT、PT及钠离子水平较对照组高,Fbg水平较对照组低(均P<0.05)。不同病情颅脑损伤患者suPAR、APTT、PT及钠离子水平比较:重型组>中型组>轻型组(均P<0.05)。所有患者均成功完成随访,预后良好患者75例,预后不良患者41例,预后不良组suPAR、APTT、PT及钠离子水平明显高于预后良好组(P<0.05)。Pearson结果显示:颅脑损伤患者suPAR、APTT、PT及钠离子与GOS评分呈正相关(P<0.05)。结论suPAR、凝血功能及血清钠离子水平是影响颅脑损伤患者病情进展、预后的重要指标,临床可通过检测suPAR、凝血功能及血清钠离子水平评估颅脑损伤患者病情进展及预后情况。Objective To investigate the relationship between plasma suPAR,coagulation function and serum sodium ion level and their disease condition and prognosisin patients with craniocerebral injury.Methods 116 patients with craniocerebral injury who were admitted to our hospital from May 2018 to May 2021 were retrospectively selected and set as the study group,with 39 severe cases,36 moderate cases,and 41 mild cases.And 104 healthy people who underwent physical examination in the same time period were selected as the control group.The levels of suPAR,APTT,PT,Fbg and sodium ion in different populations were compared.Follow-up data were collected.And the correlation between the levels of suPAR,APTT,PT,Fbg and sodium ion and prognosis in patients with craniocerebral injury was analyzed.Results The levels of suPAR,APTT,PT and sodium ion in the study group were higher than those in the control group,and the level of Fbg was lower than that in the control group(P<0.05).Comparison of suPAR,APTT,PT and sodium ion levels in patients with craniocerebral injury in different conditions:severe group>medium group>mild group(P<0.05).All patients were successfully followed up,there were 75 patients with good prognosis and 41 patients with poor prognosis,the levels of suPAR,APTT,PT and sodium ion in the poor prognosis group were significantly higher than those in the good prognosis group(P<0.05).Pearson results showed that suPAR,APTT,PT and sodium ion were positively correlated with GOS score in patients with craniocerebral injury(P<0.05).Conclusion suPAR,coagulation function and serum sodium ion level are important indicators affecting the disease progression and prognosis of patients with craniocerebral injury,clinically,the progress and prognosis of patients with craniocerebral injury can be evaluated by detecting suPAR,coagulation function and serum sodium ion level.

关 键 词：颅脑损伤 可溶性尿激酶型纤溶酶原激活物受体 凝血功能 钠离子 

分 类 号：R651.15[医药卫生—外科学]