血清戊糖素对糖尿病勃起功能障碍的诊断效能研究  

Diagnostic efficacy of serum pentosidine on diabetic erectile dysfunction

作　　者：曹宇艳 张青[1] 刘娟[1] 邵迪 盛笑 叶新华[1] Cao Yu-yan;Zhang Qing;Liu Juan;Shao Di;Sheng Xiao;Ye Xin-hua(Department of Endocrinology,Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University,Changzhou,Jiangsu 213003,China)

机构地区：[1]南京医科大学附属常州市第二人民医院内分泌及代谢病科,江苏常州213003

出　　处：《中国现代医学杂志》2023年第11期75-80,共6页China Journal of Modern Medicine

基　　金：常州市卫健委青年人才培养计划(No:CZQM2020078);常州市科技计划(No:CJ20210111);江苏省基础研究计划(自然科学基金)青年基金项目(No:BK20200178)。

摘　　要：目的探讨血清戊糖素作为糖尿病勃起功能障碍患者血清学标志物的诊断效能。方法收集2021年3月—2022年5月在南京医科大学附属常州市第二人民医院内分泌及代谢病科住院的40例2型糖尿病患者的临床资料,根据RigiScan^(TM)检查结果将其分为糖尿病勃起功能障碍组和糖尿病非勃起功能障碍组。比较两组患者的临床资料、血清戊糖素水平、有效勃起次数和有效勃起时长;采用Pearson法分析血清戊糖素和临床指标之间的相关性;绘制受试者工作特征(ROC)曲线评估血清戊糖素对糖尿病勃起功能障碍的诊断效能。结果糖尿病勃起功能障碍组血清戊糖素水平较糖尿病非勃起功能障碍组升高(P<0.05);血清戊糖素水平与UA/CR(r=0.343,P<0.05)呈正相关,与有效勃起次数(r=-0.397,P<0.05)和有效勃起时长(r=-0.403,P<0.05)呈负相关;糖尿病勃起功能障碍的患病率随着血清戊糖素的升高而升高;其曲线下面积(AUC)为0.785,敏感性为90.91%。结论血清戊糖素有望成为糖尿病勃起功能障碍新的血清学标志物。Objective To investigate the diagnostic efficacy of serum pentosidine as a biomarker in patients with diabetic erectile dysfunction.Methods Forty patients with type 2 diabetes were included and divided into diabetic erectile dysfunction and diabetic non-erectile dysfunction groups based on the RigiScan^(TM) test results.The differences between their clinical data and serum pentosidine levels were compared,and the correlation between serum pentosidine and clinical indicators was analyzed.The diagnostic efficacy of serum pentosidine in the diagnosis of diabetic erectile dysfunction was assessed by a one-way ROC curve.Results Serum pentosidine levels were significantly higher in the diabetic erectile dysfunction group compared to the diabetic non-erectile dysfunction group(P<0.05);serum pentosidine level was positively correlated with UA/CR(r=0.343,P<0.05),were negatively correlated with the number of erectile events(r=-0.397,P<0.05)and erection duration(r=-0.403,P<0.05);the prevalence of diabetic erectile dysfunction increased with the rise in serum pentosidine;the receiver operating characteristic curve had the AUC of 0.785 and the sensitivity of 90.91%.Conclusion Serum pentosidine is expected to be a new marker for diabetic erectile dysfunction.

关 键 词：糖尿病 勃起功能障碍 血清戊糖素 

分 类 号：R587.1[医药卫生—内分泌]