输血相容性检测实验室RhD血型检测策略专家共识  

Expert consensus on RhD blood group testing strategies in blood transfusion compatibility testing laboratories

作　　者：输血相容性检测实验室RhD血型检测策略专家共识编写组 马春娅[2] 李小飞 姬艳丽[4] 于洋[2] 邵超鹏[5] 付涌水[4] Expert Consensus Writing Group on RhD Blood Group Testing Strategies for Blood Transfusion Compatibility Testing Laboratories

机构地区：[1]不详 [2]解放军总医院第一医学中心 [3]首都医科大学附属友谊医院 [4]广州血液中心 [5]深圳市第二人民医院/深圳大学第一附属医院

出　　处：《中国输血杂志》2023年第5期365-372,共8页Chinese Journal of Blood Transfusion

摘　　要：RhD抗原是Rh血型系统最具免疫原性的抗原,可导致溶血性输血反应(HTRs)和胎儿与新生儿溶血病(HDFN)。我国RhD阴性红细胞属于稀缺资源,RhD阴性患者及时输注红细胞面临资源挑战。对于初筛(盐水法)为RhD阴性的不同人群,使用何种检测策略、如何出具检测报告、何时需要鉴定“亚洲型”DEL(RHD*01EL.01,c.1227G>A)是临床输血工作者较为困惑的问题。本共识由国内200余位输血相容性检测技术专家进行深入探讨后完成,旨在进一步规范、细化RhD血型检测策略,为实现不同RhD血型患者精准输血,不断提高RhD-HTRs及RhD-HDFN的防治水平提供技术支撑,为今后制定RhD血型检测策略行业标准奠定基础。RhD antigen is the most immunogenic antigens in the Rh blood group system and can cause hemolytic transfusion reactions(HTRs)and severe hemolytic disease of the fetus and newborn(HDFN).RhD-negative red blood cell(RBC)is a scarce resource in China,and RhD-negative patients face challenges in timely blood transfusion.For different populations that were initially negative for RhD(saline method),what techniques should be used,how to issue test report and when should"Asian type"DEL(RHD*01EL.01,c.1227G>A)be identified are the confusions of blood transfusion workers in the process of clinical blood supply.More than 200 technical experts discussed and reached a consensus on blood transfusion compatibility testing for Chinese population.The purpose of the consensus is to further standardize and refine the RhD blood group testing strategy,provide technical support for achieving accurate blood transfusion for patients with different RhD blood groups,continuously improve the levels of prevention and treatment for RhD-HTRs and RhD-HDFN,and lay a foundation for the future development of industry standards concerning RhD blood group testing strategy.

关 键 词：RHD血型 孕产妇 受血者 献血者 规范化 专家共识 

分 类 号：R457.1[医药卫生—治疗学]