我国儿童输血反应发生率的Meta分析  

Incidence of adverse transfusion reactions in Chinese children:a meta-analysis

作　　者：李泽 张嘉懿[1] 马佳 贺沁 LI Ze;ZHANG Jiayi;MA Jia;HE Qin(Clinical Laboratory of Tianjin Children's Hospital,Tianjin 300400,China)

机构地区：[1]天津市儿童医院检验科,天津300400

出　　处：《中国输血杂志》2023年第5期384-388,共5页Chinese Journal of Blood Transfusion

基　　金：天津市医学重点学科(专科)建设项目资助(TJYX2DXK-040A)。

摘　　要：目的系统评价我国儿童输血反应发生率,为其预防和提早干预提供科学依据。方法使用计算机检索中英文文献数据库PubMed、EMbase、The Cochrane Library、CNKI、万方和维普数据库,辅以手工检索方法,查找有关国内儿童输血反应发生率的研究文献,检索时间为2000年1月至2022年12月。由2名研究人员根据纳入及排除标准独立筛选文献、提取文献数据,并根据AHRQ质量评价量表对纳入研究进行质量评价。采用Stata 14.0软件进行统计学分析。结果检索文献共870篇,最终纳入研究文献13篇,总输血病例181274例。Meta分析结果显示,国内儿童总体输血反应发生率为0.79%[95%CI(0.54%,1.04%)];不同类型血液制品输血反应的发生率分别为红细胞0.34%[95%CI(0.15%,0.54%)]、血小板2.94%[95%CI(1.60%,4.28%)]、血浆0.31%[95%CI(0.19%,0.43%)];不同类型输血反应发生率分别为发热反应0.22%[95%CI(0.13%,0.31%)],过敏反应0.46%[95%CI(0.30%,0.61%)]。结论我国儿童总体输血反应发生率较低,但血小板输注反应率较高,在临床用中需进一步进行预防和控制。Objective To systematically evaluate the incidence of adverse transfusion reactions in Chinese children,so as to provide scientific basis for prevention and early intervention.Methods Literature databases such as PubMed,EMbase,The Cochrane Library,CNKI,Wanfang and VIP were searched in terms of the incidence of adverse transfusion reactions in Chinese children from January 2000 to December 2022.Two researchers extracted literature data independently according to the inclusion and exclusion criteria and conducted quality evaluation of included studies according to AHRQ quality evaluation scale.Statistical analysis was performed using Stata 14.0 software.Results A total of 870 literatures were retrieved,and 13 were included in the study,with a total of 181274 cases with blood transfusion.Meta-analysis showed that the overall incidence of adverse transfusion reactions in Chinese children was 0.79%[95%CI(0.54%,1.04%)].The incidence of adverse reactions of red blood cells,platelets and plasma were 0.34%[95%CI(0.15%,0.54%)],2.94%[95%CI(1.60%,4.28%)]and 0.31%[95%CI(0.19%,0.43%)],respectively.The incidence of fever reaction and anaphylaxis reaction were 0.22%[95%CI(0.13%,0.31%)]and 0.46%[95%CI(0.30%,0.61%)]respectively.Conclusion The overall incidence of adverse transfusion reactions in Chinese children is low,but the incidence of adverse reactions of platelet transfusion is high,which needs further prevention and control.

关 键 词：输血反应 儿童 发生率 META 发热反应 过敏反应 血液成分 

分 类 号：R457.13[医药卫生—治疗学] R720.5[医药卫生—临床医学]