SMIM1在Vel血型、肿瘤和疟原虫感染中的研究进展  

Research progress of SMIM1 in Vel blood type,tumor and plasmodium infection

作　　者：肖潘 刘瑜琳 汪德清 XIAO Pan;LIU Yulin;WANG Deqing(Department of Transfusion Medicine,the First Medical Center,Chinese PLA General Hospital,Beijing 100039,China;College of Clinical Medicine,Southwest Medical University)

机构地区：[1]中国人民解放军总医院第一医学中心输血医学科,北京100039 [2]西南医科大学临床医学院

出　　处：《中国输血杂志》2023年第5期459-462,共4页Chinese Journal of Blood Transfusion

基　　金：国家自然科学基金面上项目(32071117)。

摘　　要：小整合膜蛋白1(small integral membrane protein 1,SMIM1)基因编码Vel血型抗原,其外显子3中17个碱基对纯合缺失导致Vel抗原阴性。Vel阴性是稀有表型,对其准确鉴定对预防输血反应尤为重要。SMIM1蛋白除作为Vel血型抗原外,近年来生物信息学分析提示SMIM1可能是1种新的肿瘤标志物,参与众多肿瘤的发生发展。由于SMIM1蛋白与糖蛋白有类似结构,且在感染恶性疟原虫的红细胞中被磷酸化,推测SMIM1蛋白可能参与了疟疾的发展。因此,本文就近年来SMIM1和其编码蛋白在Vel血型、肿瘤和疟原虫感染方面的相关研究做一综述。Small integral membrane protein 1(SMIM1)gene encodes Vel blood group antigen,and homozygous deletion of 17 bases pairs in its exon 3 leads to Vel negative phenotype.As a rare phenotype,accurate identification and prevention of transfusion reaction for Vel negative phenotype is particularly important.In addition to serving as a Vel blood group antigen,recent bioinformatics analysis suggests that SMIM1 protein may be a new tumor biomarker involved in the occurrence and development of numerous tumors.Due to the similarity in structure between SMIM1 protein and glycoprotein,and its phosphorylation in red blood cells infected with Plasmodium falciparum,it is speculated that SMIM1 protein may be involved in the development of malaria.Therefore,this article provides a review of the related research on SMIM1 and its coding protein in Vel blood type,tumor and plasmodium infection.

关 键 词：SMIM1 Vel血型抗原 肿瘤标志物 疟疾 

分 类 号：R457.11[医药卫生—治疗学]