2017-2021年甘肃省慢性丙型肝炎流行病学调查  

Survey on epidemiological characteristics of chronic hepatitis C in Gansu province from 2017 to 2021

作　　者：王娟霞[1,2] 漆润琳 魏世博 李佳昊 黄子龙 赵有利[1,3] WANG Juanxia;QI Runlin;WEI Shibo;LI Jiahao;HUANG Zilong;ZHAO Youli(The Second Clinical Medical College of Lanzhou University,Gansu 730030,China;Department of Infectious Diseases,Lanzhou University Second Hospital;Clinical Laboratory Medicine Center,Lanzhou University Second Hospital)

机构地区：[1]兰州大学第二临床医学院,甘肃730030 [2]兰州大学第二医院感染性疾病科 [3]兰州大学第二医院检验医学中心

出　　处：《预防医学论坛》2023年第4期256-260,281,共6页Preventive Medicine Tribune

基　　金：甘肃省自然科学基金项目(22JR5RA1000);兰州大学第二临床医学院校创项目(20220050109)。

摘　　要：目的分析2017-2021年兰州大学第二医院确诊慢性丙型肝炎(丙肝)患者的流行病学资料,明确丙肝病毒抗体(抗-HCV)阳性患者地区和职业分布特征及HCV基因型构成特点,以确定HCV感染重点筛查人群。方法收集该院2017-2021年门诊和住院患者筛查抗-HCV资料,剔除同一患者多次检查结果,比较不同年份、性别、年龄段及科室抗-HCV阳性构成比和率的差异,计算已分型HCV基因型构成比;分析2011-2021年该院新发丙肝患者的地区和职业分布特点。结果2017-2021年筛查平均抗-HCV阳性率为0.98%;男女抗-HCV阳性率差异无统计学意义(P=0.09);56~70岁抗-HCV阳性患者占总阳性例数最多,且年龄越大抗-HCV阳性率越高;门诊科室中便民门诊、急诊及内科,住院科室中急诊、内科及外科抗-HCV阳性率高,均达到1.00%以上。共分型1346例,HCV基因型以1b和2a型占比高,分别为42.35%和52.30%。该院2011-2021年共报告新发丙肝确诊患者3661例,由于患者信息存在缺失,故分别获得3608例患者地区信息、3466例患者职业信息。前者兰州市占比48.00%(1734例);后者农民占比38.20%(1324例),其次为服务业(728例)和离退人员(723例)。多重对应分析结果提示抗-HCV阳性高危人群与急诊(含门诊和住院)、内科(住院)、外科(住院)及40岁以上年龄段有较强的关联性。结论2017-2021年甘肃省丙肝患者以中老年患者高发,门诊和住院各科室抗-HCV阳性率存在差异。HCV基因型以1b型和2a型为主。新发丙肝患者高发地区为兰州市,高发人群为农民。Objective By analyzing the data of hepatitis C patients diagnosed in the second hospital of Lanzhou university from 2017 to 2021,the distribution characteristics of hepatitis C virus antibody(anti-HCV)positive patients and HCV genotype were clarified,so as to determine the key screening population of HCV infection.MethodsThe anti-HCV screening data of outpatient and inpatient patients from the hospital during 2017 to 2021 were collected,and the multiple examination results of the same patient were excluded.The difference of anti-HCV positive proportion and rate among different years,gender,ages and departments were compared and analyzed.The genotype proportion of HCV was calculated.The regional and occupational distribution characteristics of newly diagnosed hepatitis C patients in the hospital from 2011 to 2021 were analyzed.Results The average anti-HCV positive rate from 2017 to 2021 was 0.98%.There was no significant difference in anti-HCV positive rate between male and female(P=O.09).Anti-HCV-positive patients aged 56 to 70 years accounted for the highest number of total positive cases,and the rate of anti-HCV positivity increased with age;The anti-HCV positive rates of the convenient outpatient department,emergency department and internal medicine among the outpatient departments as well as emergency department,internal medicine and surgery among the inpatient departments were high(more than 1.00%).A total of 1346 cases were classified,of which 1b and 2a accounted for 42.35%and 52.30%respectively.A total of 3661 new confirmed cases of hepatitis C were reported at the hospital from 2011-2021,and information on the region of 3608 patients and the occupation of 3466 patients was obtained separately because of missing patient information.Lanzhou accounted for 48.oo%(1734 cases)in the former,and the farmers accounted for 38.20%(1324 cases)in the latter,followed by the service industry(728 cases)and retired personnel(723 cases).The results of multiple correspondence analysis suggested that the high-risk population

关 键 词：丙型肝炎病毒抗体 基因分型 甘肃省 流行病学 

分 类 号：R512.6[医药卫生—内科学]