正己烷体内外诱导毒性效应的机制研究进展  

Progress on the mechanism of n-hexane induced toxic effects in vitro and in vivo

作　　者：张连婧 冯文艇 刘建军 Zhang Lianjing;FengWenting;Liu Jianjun(Guangdong Medical University School of Public Health,Shenzhen 518020,China;Shenzhen Institute of Occupational Disease Control and Prevention,Occupational Health Care Institute Guangdong,Shenzhen 518020,China;Shenzhen Key Laboratory of Modern Toxicology,Shenzhen Center for Disease Control and Prevention,Shenzhen Health Toxicology Medical Key Discipline(2020-2024),Shenzhen 518020,China)

机构地区：[1]广东医科大学公共卫生学院,深圳518020 [2]深圳市职业病防治院职业健康监护所,深圳518020 [3]深圳市疾病预防控制中心,深圳市现代毒理学重点实验室,深圳市卫生毒理学医学重点学科(2020-2024年),深圳518020

出　　处：《中华劳动卫生职业病杂志》2023年第5期388-396,共9页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：深圳市科技创新委员会基础研究项目(JCYJ20190808175601651);广东省医学科学技术研究基金(A2022438);深圳市医学重点学科建设经费资助项目(SZXK069);深圳市医疗卫生三名工程项目(SZSM201611090)。

摘　　要：正己烷是被广泛应用的一种有机溶剂,慢性正己烷中毒为我国主要的职业中毒之一。特别是周围神经系统远端粗纤维的轴索和髓鞘病变,可能由正己烷在人体内的中间代谢产物2,5-己二酮(2,5-HD)引起。正己烷不仅对神经系统有毒性作用,且有肝、肾和生殖性。本文以正己烷中毒性神经病变的机制研究进展进行综述。Hexane is a widely used organic solvent in industry,and chronic hexane poisoning is the main occupational toxic lesion in China.In particular,axonal and myelin lesions in the distal thick fibers of the peripheral nervous system may be caused by 2,5-hexanedione(2,5-HD),an intermediate metabolite of n-hexane in humans.Hexane has toxic effects not only on the nervous system but also on the liver,kidneys,and reproductive organs.In this paper,we review the progress of research on the mechanism of n-hexane toxic neuropathy.

关 键 词：正己烷 2 5-己二酮 毒性效应 机制研究 慢性 

分 类 号：R135.1[医药卫生—劳动卫生]