骨髓增殖性肿瘤所致假性低血糖1例报道  

Pseudohypoglycemia caused by myeloproliferative neoplasms:a case report

作　　者：邵文琦 朱丽娜 王蓓丽 潘柏申 郭玮 SHAO Wen-qi;ZHU Li-na;WANG Bei-i;PAN Bai-shen;GUO Wei(Department of Clinical Laboratory,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Department of Laboratory Medicine,Zhongshan Hospital(Xiamen Branch),Fudan University,Xiamen 361015,Fujian Province,China)

机构地区：[1]复旦大学附属中山医院检验科,上海200032 [2]复旦大学附属中山医院厦门医院检验科,厦门361015

出　　处：《复旦学报（医学版）》2023年第3期467-470,474,共5页Fudan University Journal of Medical Sciences

基　　金：国家自然科学基金面上项目(81972000,81902139,82172348);复旦大学附属中山医院临床研究专项基金(2018ZSLC05);厦门市医疗卫生重点项目(YDZX20193502000002)。

摘　　要：复旦大学附属中山医院曾收治1例反复异常低血糖患者,男性,69岁,因上腹部胀痛就诊于我院急诊,诊断为消化道穿孔,行十二指肠修补术,转入普外科,术后禁食予深静脉补充营养液(含葡萄糖500 mL)。患者反复空腹低血糖,血清/血浆葡萄糖结果波动于0.5~1.7 mmol/L,以“无症状持续低血糖10余天”转诊至内分泌科继续治疗。临床医师反馈患者无任何低血糖相关症状和反应,通过数据整理、原因分析和文献回顾,最终以骨髓增殖性肿瘤致假性低血糖处理,患者转诊至血液科。A male patient of 69 years old with recurrent abnormal hypoglycemia was admitted to Zhongshan Hospital,Fudan University.He was admitted to the department of emergency because of upper abdominal pain.The diagnosis was gastrointestinal perforation,duodenal repair was performed,and he was transferred to general surgery ward with order fasting and supplement solution containing glucose 500 mL ivgtt.Due to repeated fasting hypoglycemia and serum/plasma glucose results fluctuated between 0.5 and 1.7 mmol/L,the patient was referred to the department of endocrinology for continued treatment with asymptomatic persistent hypoglycemia for more than 10 days.Clinicians reported that the patient did not have any hypoglycemia-related symptoms and reactions.According to this clinical feedback,the corresponding data collation,cause analysis and literature review were performed.Finally,the patient was treated with pseudo hypoglycemia caused by myeloproliferative neoplasms and referred to the department of hematology for subsequent treatment.

关 键 词：假性低血糖 骨髓增殖性肿瘤 检测干扰 糖酵解 

分 类 号：R544.2[医药卫生—心血管疾病]