49-2游泳池反应堆辐照生产^(90)Y的可行性研究  

Feasibility Study for Irradiation Production of^(90)Y by 49-2 Pool Reactor

作　　者：左亚杰 陈晓亮[1] 张宇[1] 张伟坚 王硕[1] 陈效先[1] ZUO Yajie;CHEN Xiaoliang;ZHANG Yu;ZHANG Weijian;WANG Shuo;CHEN Xiaoxian(China Institute of Atomic Energy,Beijing 102413,China)

机构地区：[1]中国原子能科学研究院,北京102413

出　　处：《同位素》2023年第3期279-284,共6页Journal of Isotopes

摘　　要：^(90)Y是一种较理想的治疗用放射性核素,其标记的放射性药物被广泛用于多种癌症的诊断和治疗。49-2游泳池反应堆(简称49-2堆)是放射性同位素生产的优良平台,为验证49-2堆辐照生产^(90)Y同位素的可行性,利用蒙特卡罗程序MCNP6(Monte Carlo N-particle 6)与SCALE6.1程序,计算在49-2堆芯内E8、H8、D10三个典型位置处辐照高纯氧化钇(Y 2O 3)靶生产放射性同位素^(90)Y的活度,并与H8位置的辐照实验结果进行对比。理论计算结果表明:E8孔道是最佳辐照位置,孔道平均中子通量密度为1.09×1014 n/(cm-2·s);E8、H8孔道可生产高比活度的^(90)Y(>10 Ci/g),所需辐照时间分别为2、6 d;辐照产生的放射性同位素^(90)Y中杂质核素含量较低(<105)。与49-2堆内H8孔道处^(90)Y辐照实验结果对比,偏差为4.02%。以上结果表明,利用49-2堆辐照高纯Y 2O 3靶可生产满足医用标准的^(90)Y同位素。^(90)Y is an ideal therapeutic radionuclide,and its labeled radiopharmaceuticals are widely used in the diagnosis and treatment of a variety of cancers.In order to verify the feasibility of irradiating the 49-2 reactor to produce^(90)Y isotopes,the activity of irradiating high-purity yttrium oxide(Y 2O 3)targets to produce radioisotopes^(90)Y in the 49-2 core was calculated by using the Monka program MCNP6(Monte Carlo N-particle 6)and SCALE6.1.It was compared with the results of irradiation experiments at the H8 position.The theoretical calculation results show that E8 and H8 pores can produce^(90)Y(>10 Ci/gY)with high specific activity,the irradiation time required is 2 days and 6 days,respectively,and the content of impurity nuclides in the radioactive isotope^(90)Y produced by irradiation is low(<105).Compared with the results of^(90)Y irradiation experiment at H8 hole in the reactor of 49-2,the deviation was 4.02%.The results show that^(90)Y isotopes that meet medical requirements can be produced by irradiating high-purity yttrium oxide targets with 49-2 reactors.

关 键 词：游泳池反应堆 同位素生产 ^(90)Y 

分 类 号：TL92[核科学技术—核燃料循环与材料]