生长板损伤后骨桥形成分子机制的研究进展  

Research progress on the molecular mechanism of bone bridge formation after growth plate injury

作　　者：任廷果 彭国璇 孙红 林廉洋 彭洪成 黄明智 姜华 邓进 Ren Tingguo;Peng Guoxuan;Sun Hong;Lin Lianyang;Peng Hongcheng;Huang Mingzhi;Jiang Hua;Deng Jin(School of Clinical Medicine,Guizhou Medical University,Guiyang 550025,China;Department of Emergency Medicine,Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China;Department of Orthopedics,Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China;Department of Pediatric Orthopedics,Guizhou Provincial Orthopaedic Hospital,Guiyang 550007,China;Pediatric Surgery,Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China)

机构地区：[1]贵州医科大学临床医学院,贵阳550025 [2]贵州医科大学附属医院急诊医学科,贵阳550004 [3]贵州医科大学附属医院骨科,贵阳550004 [4]贵州省骨科医院小儿骨科,贵阳550007 [5]贵州医科大学附属医院小儿外科,贵阳550004

出　　处：《创伤外科杂志》2023年第6期464-470,共7页Journal of Traumatic Surgery

基　　金：国家自然科学基金(81660317);贵州省科技计划(黔科合SY字[2015]3014)。

摘　　要：生长板损伤或骨骺损伤是由创伤、感染等因素导致的长骨生长板软骨损伤。生长板损伤后会引起骨骺与干骺端之间形成骨桥,由此导致的肢体短缩与成角畸形一直是小儿矫形外科医师面临的重大挑战。软骨内成骨参与了生长板损伤后骨桥的形成,许多细胞因子及转录因子通过控制软骨内成骨程序在骨桥形成中扮演重要角色,如血管内皮生长因子、印度刺猬因子、成纤维细胞生长因子受体3、炎症相关因子以及缝隙引导配体3等细胞因子的分泌异常会导致生长板损伤后软骨细胞的增殖与分化功能受损,进而影响软骨内成骨活动。因此,本文综述生长板损伤后骨桥形成的相关分子调控机制,旨在为生长板损伤治疗提供新思路。Growth plate injury,or called epiphyseal injury,is the cartilage damage of the growth plate of long bones caused by trauma,infection,etc.The shortening and angulation of limbs resulting from the formation of bone bridges between the epiphysis and the metaphysis after growth plate injuries has been a major challenge for pediatric orthopaedic surgeons.Endochondral ossification is involved in the formation of bone bridges after growth plate injuries.Many cytokines and transcription factors play important roles in the formation of bone bridges by controlling the endochondral ossification program.For example,abnormal secretion of cytokines such as vascular endothelial growth factor,Indian hedgehog factor,fibroblast growth factor receptor 3,inflammation-related factors,and Slit guidance ligand 3 leads to impaired proliferation and differentiation of chondrocytes after growth plate injuries,which in turn affects the osteogenic activity within cartilage.Therefore,this paper intends to review the molecular regulatory mechanisms related to bone bridge formation after growth plate injuries,aiming to provide new ideas for the treatment of such injuries.

关 键 词：生长板损伤 骨桥形成 分子机制 

分 类 号：R683[医药卫生—骨科学]