利奈唑胺葡萄糖注射液药物利用评价标准的建立及在重症医学科的应用  

Establishment of drug use evaluation criteria for linezolid injection and its application in intensive care unit

作　　者：张正升[1] 周家军[1] 刘建军[1] ZHANG Zhengsheng;ZHOU Jiajun;LIU Jianjun(Department of Pharmacy,The Second People's Hospital of Hefei(Hefei Hospital Affiliated to Anhui Medical University),Hefei,Anhui 230011,China)

机构地区：[1]合肥市第二人民医院(安徽医科大学附属合肥医院)药学部,安徽合肥230011

出　　处：《安徽医药》2023年第7期1472-1475,共4页Anhui Medical and Pharmaceutical Journal

基　　金：合肥市第二人民医院院级光华基金科研项目(2019第171-5号)。

摘　　要：目的建立利奈唑胺葡萄糖注射液的药物利用评价(DUE)标准,评价利奈唑胺葡萄糖注射液在重症医学科(ICU)的应用情况,为临床合理用药提供参考。方法参考药品说明书、抗菌药物临床应用指导原则、相关管理规范,建立利奈唑胺葡萄糖注射液的DUE标准,并对2020年7月至2021年12月合肥市第二人民医院ICU使用利奈唑胺葡萄糖注射液的病历进行回顾性分析。结果共纳入应用利奈唑胺葡萄糖注射液的病人82例,临床有效率52.44%(43/82)、药品不良反应(ADR)发生率4.88%(4/82),经评估该院ICU的利奈唑胺葡萄糖注射液应用在剂量、处方权限、病程记录、不良反应监测方面均符合评价标准要求,但仍有一些指标存在问题,如经验性用药较多89.02%(73/82)、用药前病原学检查率较低48.78%(40/82)、药物疗程不足45.12%(37/82),主要由病人出院或发生ADR造成。结论建立的利奈唑胺葡萄糖注射液的DUE标准实用性较强,可及时发现利奈唑胺葡萄糖注射液在使用过程中的问题。Objective To establish the Drug Use Evaluation(DUE)criteria for linezolid injection,and to evaluate the clinical efficacy and rationality of linezolid injection in Intensive Care Unit(ICU),so as to provide reference for clinical rational drug use.Methods The DUE criteria for linezolid injection was established by referring to drug instructions,guiding principles of clinical application of antibiotics,and relevant management specification.Additionally,the medical records of linezolid injection used in ICU of Second People's Hospital of Hefei from July 2020 to December 2021 were retrospectively analyzed according to this standard.Results A total of 82 patients who used linezolid injection were enrolled in this study,with a clinical effective rate of 52.44%(43/82)and an incidence of adverse drug reactions(ADR)of 4.88%(4/82).After evaluation,the dosage frequency,prescription authority,progress notes and the ADR monitoring met the requirement of evaluation criteria.However,there were still some problematic indicators,such as high empirical medication of 89.02%(73/82),low pre-medication etiological examination rate of 48.78%(40/82),and insufficient course of treatment rate of 45.12%(37/82),mainly because of discharge or ADR.Conclusion The established evaluation criteria for the use of linezolid injection have good practicability,and problems in the use of linezolid injection could be found in time.

关 键 词：利奈唑胺 处方不当 药物利用评价 重症医学科 药物耐受性 

分 类 号：R95[医药卫生—药学]