基于磁共振扩散张量成像探讨慢性酒精中毒性脑病胼胝体变性ADC值、FA值与饮酒年限的关系及变化趋势  

Exploring the Relationship between ADC and FA Values of Corpus Callosum Degeneration and Years of Alcohol Consumption in Chronic Alcoholic Encephalopathy Based on Magnetic Resonance Diffusion Tensor Imaging and the Trend of Change

作　　者：陆涛[1] 李欢欢[1] 黄叶梅 黄德尤[1] 陈炯[2] LU Tao;LI Huan-huan;HUANG Ye-mei;HUANG De-you;CHEN Jiong(The Affiliated Hospital of Youjiang Medical College for Nationalities,Baise 533000,Guangxi Province,China;Nanning Second People's Hospital,Nanning 530000,Guangxi Province,China)

机构地区：[1]右江民族医学院附属医院,广西百色533000 [2]南宁市第二人民医院,广西南宁530000

出　　处：《中国CT和MRI杂志》2023年第6期4-7,共4页Chinese Journal of CT and MRI

基　　金：磁共振成像对慢性酒精中毒性脑病患者胼胝体变性的诊断价值研究(yy2021sk037)。

摘　　要：目的基于磁共振扩散张量成像(DTI)探究慢性酒精中毒性脑病(CAE)胼胝体变性患者表观弥散系数(ADC)值、各向异性分数(FA)值与饮酒年限的关系及变化趋势。方法选取2018年7月至2022年12月我院60例CAE胼胝体变性患者作为研究组,另选同期60例无饮酒史健康志愿者作为对照组。两组均行DTI检查,比较两组一般资料、胼胝体DTI参数(ADC值、FA值),并比较研究组不同饮酒年限患者ADC值、FA值,分析CAE胼胝体变性患者饮酒年限与ADC值、FA值的相关性,采用受试者工作特征(ROC)曲线、决策曲线(DCA)分析ADC值、FA值诊断CAE胼胝体变性的价值及临床效用,通过危险度分析ADC值、FA值与CAE胼胝体变性发生风险的关系。结果研究组胼胝体膝部、体部、压部ADC值及平均ADC值均高于对照组,胼胝体膝部、体部、压部FA值及平均FA值均低于对照组(P<0.05);研究组胼胝体膝部、体部、压部ADC值及平均ADC值均随饮酒年限增加逐渐增大,胼胝体膝部、体部、压部FA值及平均FA值均随饮酒年限增加逐渐减小(P<0.05);研究组患者胼胝体膝部、体部、压部ADC值及平均ADC值均与饮酒年限呈正相关,胼胝体膝部、体部、压部FA值及平均FA值均与饮酒年限呈负相关(P<0.05);胼胝体平均ADC值、FA值诊断CAE胼胝体变性的曲线下面积(AUC)分别为0.709、0.826,联合诊断的AUC最大,为0.924,诊断敏感度、特异度分别为86.67%、83.35%,在CAE胼胝体变性诊断方面具有良好临床效用;胼胝体平均ADC值≥6.20×10^(-3)mm^(2)/s(OR=5.934)、平均FA值≤0.28(OR=9.036)均会明显增加CAE胼胝体变性发生风险(P<0.05)。结论DTI参数ADC值、FA值与CAE胼胝体变性患者饮酒年限密切相关,ADC值随饮酒年限增加逐渐增大,FA值随饮酒年限增加逐渐减小,二者在CAE胼胝体变性诊断方面具有良好诊断价值和临床效用。Objective To investigate the relationship between apparent diffusion coefficient(ADC)values,anisotropy fraction(FA)values and years of alcohol consumption in patients with chronic alcoholic encephalopathy(CAE)with corpus callosum degeneration based on magnetic resonance diffusion tensor imaging(DTI)and the trend of change.Methods Sixty patients with CAE corpus callosum degeneration in our hospital from July 2018 to December 2022 were selected as the study group,and another 60 healthy volunteers with no history of alcohol consumption in the same period were selected as the control group.DTI examination was performed in both groups,and the general data and corpus callosum DTI parameters(ADC values and FA values)were compared between the two groups,and the ADC values and FA values of patients with different years of alcohol consumption in the study group were compared,and the correlation between the years of alcohol consumption and ADC values and FA values of patients with CAE corpus callosum degeneration was analyzed,and the ADC values and FA values were diagnosed using subject work characteristic(ROC)curves and decision curves(DCA)The value and clinical utility of CAE corpus callosum degeneration,and the relationship between ADC value,FA value and the risk of CAE corpus callosum degeneration by risk level analysis.Results The ADC values and mean ADC values of the corpus callosum knee,body,and compression were higher in the study group than in the control group,and the FA values and mean FA values of the corpus callosum knee,body,and compression were lower than in the control group(P<0.05);the ADC values and mean ADC values of the corpus callosum knee,body,and compression in the study group gradually increased with increasing years of alcohol consumption,and the FA values and mean FA values of the corpus callosum knee,body,and compression gradually decreased with increasing years of alcohol consumption(P<0.05).The FA values and mean FA values of the corpus callosum knee,body,and pressure all gradually increased wit

关 键 词：慢性酒精中毒性脑病 胼胝体变性 磁共振扩散张量成像 诊断 

分 类 号：R445.2[医药卫生—影像医学与核医学]