治疗前鼻咽癌患者外周血常规指标与动脉自旋标志成像的相关性及分期价值  

Correlation and Staging Value of Peripheral Blood Routine Index and Arterial Spin Labeling in Patients with Nasopharyngeal Carcinoma before Treatment

作　　者：吴文秀 徐志锋[1] 潘爱珍[1] 黄麟雯 WU Wen-xiu;XU Zhi-feng;PAN Ai-zhen;HUANG Lin-wen(Department of Radiology,The First People’s Hospital of Foshan,Foshan 528000,Guangdong province,China)

机构地区：[1]广东省佛山市第一人民医院影像科,广东佛山528000

出　　处：《中国CT和MRI杂志》2023年第6期34-36,46,共4页Chinese Journal of CT and MRI

基　　金：佛山市卫生健康局医学科研项目(20220064)。

摘　　要：目的探讨鼻咽癌患者治疗前血常规各指标与动脉标志成像(ASL)对分期的价值,血常规指标与ASL相关性。方法收集经病理证实的NPC患者48例,将临床分期Ⅰ及Ⅱ期患者归为低级别组,Ⅲ期及Ⅳ期归为高级别组,分析治疗前两组间血常规指标、血流量(BF)对分期价值,做ROC曲线。分析血常规指标与BF之间的相关性。结果高级别组淋巴细胞绝对值比低级别组低,血小板计数(PLT)、血小板与淋巴细胞比值(PLR)与肿瘤面积比低级别组高;高低级别组间,高级别组BF均值比低级别组高。BF与中性粒细胞与淋巴细胞比值(NLR)呈正相关;BF与淋巴细胞呈负相关(r=-0.307)。PLR与HB呈负相关(r=-0.564),PLR与面积呈正相关(r=0.405)。结论 鼻咽癌患者治疗前淋巴细胞减低,PLT、PLR升高,面积越大,提示分期较晚,血常规指标对鼻咽癌分期具有一定的预测价值。肿瘤灌注参数BF与NLR呈正相关,可能间接提示治疗前BF呈高灌注,患者预后较差。ASL有可能为患者个体化治疗前提供定量依据。Objective To investigate the staging value of blood routine indexes and arterial marker imaging in patients with nasopharyngeal carcinoma before treatment,and the correlation between blood routine indexes and arterial marker imaging.Methods Collected 48 cases of patients with nasopharyngeal carcinoma(NPC),which was confirmed by pathology,clinical stage in patients with clinical stage I and II are classified as low level,phase III and IV as high level group,analysis of the two groups before treatment between the blood routine,BF value of installment,ROC curve for meaningful indicators.The correlation between blood routine indexes and BF parameters was analyzed.Results The absolute value of lymphocytes in high grade group was lower than that in low grade group,while platelet count,PLR and area ratio were higher in low grade group.The mean BF of the high grade group was higher than that of the low grade group.BF was positively correlated with NLR.A negative correlation was found between BF and LYMPH(r=-0.307)..PLR was negatively correlated with HB(r=-0.564),and PLR was positively correlated with area(r=0.405).Conclusion The lymphocyte decrease,the absolute value of platelet and PLR increase,and the tumor area increase in patients with nasopharyngeal carcinoma before treatment,suggesting a higher stage.The blood routine indexes have certain predictive value for the stage of nasopharyngeal carcinoma.The tumor perfusion parameter BF was positively correlated with NLR,which may indirectly indicate that BF was highly perfusion before treatment and the prognosis of patients was poor.ASL noninvasive perfusion technique may provide quantitative evidence for patients before individualized treatment.

关 键 词：鼻咽癌 血常规 动脉自旋标志成像 血小板与淋巴细胞比值 中性粒细胞与淋巴细胞比值 

分 类 号：R445.2[医药卫生—影像医学与核医学]