原发性痛经多频段的脑区域一致性改变:一项静息态功能磁共振研究  

Brain regional homogeneity alterations in multi-frequency bands in primary dysmenorrhea:A resting-state functional magnetic resonance imaging study

作　　者：刘妮 张亚男[1] 戴娜[1] 霍健伟 张磊[1] 黄怡然[2] 刘军莲[1] LIU Ni;ZHANG Ya'nan;DAI Na;HUO Jianwei;ZHANG Lei;HUANG Yiran;LIU Junlian(Department of Radiology,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;School of Acupuncture-Moxibustion and Tuina,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京中医医院放射科,北京100010 [2]北京中医药大学针灸推拿学院,北京100029

出　　处：《磁共振成像》2023年第6期39-44,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：北京中医药大学校级纵向科研发展基金(编号:2020-ZXFZJJ-035)。

摘　　要：目的 采用多频段局部一致性(regional homogeneity, ReHo)的方法探索原发性痛经(primary dysmenorrhea,PDM)患者自发性区域神经活动异常与特定频段的相关性,并探讨ReHo值的变化是否与临床指标相关。材料与方法 纳入32例PDM患者和36例健康对照(healthy controls, HC)。所有受试者均接受静息态功能磁共振成像检查。计算常规频段(0.010~0.080 Hz)、慢-4频段(0.027~0.073 Hz)和慢-5频段(0.010~0.027 Hz)的ReHo值。采用两样本t检验比较两组间的ReHo值,并采用皮尔逊相关分析探索PDM患者ReHo值与临床指标的关系。结果 与HC相比,PDM患者在常规频段及慢-4频段上,右侧海马旁回、颞极颞上回、基底核及前扣带回ReHo值增加,左侧颞中回、颞下回及岛叶的ReHo值减低,而在慢-5频段,PDM患者右侧额中回的ReHo值增加,左侧小脑8区的ReHo值减低(体素水平P<0.001,团块水平P<0.05,FWE校正)。相关性分析表明PDM患者的COX1评分与常规频段左侧颞中回的ReHo值正相关。结论 本研究揭示了PDM中频率特异性的ReHo改变,其中,常规频段发现的与疼痛传入、情绪和记忆有关的脑区活动改变与慢-4频段基本一致,而慢-5频段则可能会提供额外的发现,为PDM的神经生物学机制提供了新的见解。Objective:To investigate whether the spontaneous regional neural activity abnormalities in patients with primary dysmenorrhea(PDM)are associated with specific frequency bands using a multifrequency bands regional homogeneity(ReHo)method and to explore whether the alteration of ReHo values is associated with clinical measures.Materials and Methods:Thirty-two PDM patients and thirty-six healthy controls(HC)were enrolled in this study and underwent resting-state functional magnetic resonance imaging.The ReHo analyses in conventional frequency band(0.010-0.080 Hz),slow-4(0.027-0.073 Hz)band and slow-5(0.010-0.027 Hz)band were conducted.Two-sample t test was used to compare the ReHo values between the two groups,and Pearson correlation analysis was used to explore the relationship between the ReHo values of PDM patients and clinical measures.Results:Compared with HC(FEW corrected,voxel P<0.001,cluster P<0.05,two tailed),PDM patients showed increased ReHo values in the right parahippocampus gyrus,temporal pole superior temporal gyrus,basal nucleus and anterior cingutate,and decreased ReHo values in the left middle temporal gyrus,inferior temporal gyrus and insula both in conventional frequency band and slow-4 band,while PDM patients showed increased ReHo values in the right middle frontal gyrus and decreased ReHo values in the left cerebellum 8 region compared with HC in slow-5 band.Correlation analysis showed that COX1 was positively correlated with ReHo values in the left middle temporal gyrus in conventional frequency band in PDM patients.Conclusions:The present study revealed frequency-specific ReHo alterations in PDM,among which,the changes in activity in brain regions associated with pain afference,emotion and memory found in the conventional band were roughly consistent with slow-4 band,while slow-5 band may provide additional findings,providing new insights into the neurobiological mechanisms of PDM.

关 键 词：原发性痛经 静息态功能磁共振成像 局部一致性 频率特异性 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R711.51[医药卫生—诊断学]