靶向表皮生长因子受体的泛素化修饰  

Ubiquitination modification targeting epidermal growth factor receptor

作　　者：张梦 汤隽[2] 张树玲[1] 赵健竹[1] ZHANG Meng;TANG Jun;ZHANG Shuling;ZHAO Jianzhu(Department of Oncology,Shengjing Hospital of China Medical University,Shenyang 110004,China;Department of Thoracic Surgery,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院肿瘤科,沈阳110004 [2]中国医科大学附属盛京医院胸外科,沈阳110004

出　　处：《中国医科大学学报》2023年第6期549-552,556,共5页Journal of China Medical University

基　　金：国家自然科学基金(82103338);北京白求恩专项研究基金(mnzl202027);中国博士后科学基金(2022M713487)。

摘　　要：表皮生长因子受体(EGFR)在细胞生长、发育和分化过程中发挥重要作用。EGFR高表达或异常激活,与包括非小细胞肺癌在内的多种肿瘤的进展和治疗耐药性有关。泛素化在EGFR蛋白翻译后修饰中扮演重要角色,参与EGFR磷酸化修饰过程。目前研究已报道多种泛素连接酶可参与EGFR的泛素化修饰,参与并调控EGFR内吞降解、药物耐药等多种病理生理机制。本文对近年发现的参与EGFR泛素化修饰的泛素连接酶及其相关机制作用进行了总结。The epidermal growth factor receptor(EGFR)plays an important role in cell growth,development,and differentiation.The high expression or abnormal activation of EGFR is related to the progression and treatment resistance of a variety of tumors including nonsmall cell lung cancer.Ubiquitination plays an important role in the post-translational modification of EGFR protein and participates in modifying EGFR phosphorylation.A variety of ubiquitin ligases reportedly participate in the ubiquitination modification of EGFR and contribute to and regulate various pathophysiological mechanisms such as EGFR endocytosis and drug resistance.This article reviews that ubiquitin ligase is involved in EGFR ubiquitination modification and related mechanisms.

关 键 词：泛素 泛素化 表皮生长因子受体 泛素连接酶 

分 类 号：R34[医药卫生—基础医学]