部分感染指标在新型冠状病毒感染病情评估中的应用  

Application of some infection indicators in assessment of novel coronavirus infection

作　　者：张文钦 陈云浩 周宪伟[1] 任更朴[1] Zhang Wenqin;Chen Yunhao;Zhou Xianwei;Ren Gengpu(Department of Clinical Laboratory,the Second People's Hospital of Liaocheng,Liaocheng 252600,Shandong,China)

机构地区：[1]聊城市第二人民医院检验科,山东聊城252600

出　　处：《实用检验医师杂志》2023年第1期80-83,共4页Chinese Journal of Clinical Pathologist

摘　　要：目的 探讨新型冠状病毒感染(新冠感染)患者的部分感染指标与病情严重程度的相关性,旨在早期识别新冠感染重症患者。方法 选择2022年12月—2023年1月聊城市第二人民医院收治的96例新冠感染患者作为研究对象,其中56例为重症,40例为非重症。使用血液分析仪,采用流式细胞术测定所有入选患者的白细胞计数(WBC)、中性粒细胞计数(NEU)及中性粒细胞比例(NEU%),使用特定蛋白即时检测分析仪,采用胶乳增强免疫比浊法检测C-反应蛋白(CRP),使用全自动生化分析仪,采用神经氨酸酶法检测血清唾液酸(SA)。收集检测结果数据并进行统计学分析,比较不同病情严重程度新冠感染患者上述指标水平的差异。绘制受试者工作特征曲线(ROC曲线)并计算ROC曲线下面积(AUC),评估各指标诊断新冠感染重症的效能。结果 新冠感染重症患者的WBC、NEU、NEU%、CRP及SA水平均明显高于非重症患者[WBC(×10^(9)/L):8.61±4.02比6.86±3.35,NEU(×10^(9)/L):7.29±3.82比5.24±3.06,NEU%:(83.05±12.40)%比(74.35±11.95),CRP(mg/L):141.21±71.02比28.16±19.00,SA(mg/L):951.38±142.74比726.80±135.60,均P<0.05]。WBC的AUC、敏感度、特异度分别为0.646、60.7%、67.5%,NEU的AUC、敏感度、特异度分别为0.683、67.9%、65.0%,NEU%的AUC、敏感度、特异度分别为0.732、66.1%、70.0%,CRP的AUC、敏感度、特异度分别为0.947、87.5%、90.0%,SA的AUC、敏感度、特异度分别为0.877、92.9%、72.5%,其中SA、CRP的诊断效率明显高于WBC、NEU、NEU%。结论 WBC、NEU、NEU%、CRP及SA水平变化对新冠感染患者病情严重程度的判断具有重要参考意义。Objective To explore the correlation between some infection indicators in patients with coronavirus infection and the severity of disease,in order to identify severe patients with coronavirus infection early.Methods The 96 patients with coronavirus infection admitted to the Second People's Hospital of Liaocheng from December 2022 to January 2023 were selected as research objects,and among them 56 patients were severe cases and 40 patients were non severe cases.The white blood cell count(WBC),neutrophil count(NEU)and neutrophil proportion(NEU%)of all patients were measured by flow cytometry,using a blood cell analyzer.The latex enhanced immune turbidimetry and specific protein real-time detection analyzer were used to detect C-reactive protein(CRP)and the neuraminidase method and automated biochemical analyzer were used to detect serum sialic acid(SA).The detection results were collected and statistically analyzed to compare the differences of the above indicators in patients with coronavirus infection of different severities.The receiver operator characteristic(ROC)curve was drawn and the area under ROC curve(AUC)was calculated to evaluate the efficacy of each index in diagnosis of severe coronavirus infection.Results The levels of WBC,NEU,NEU%,CRP and SA in severe patients with coronavirus infection were significantly higher than those in non severe patients with coronavirus infection[WBC(×10^(9)/L):8.61±4.02 vs.6.86±3.35,NEU(×10^(9)/L):7.29±3.82 vs.5.24±3.06,NEU%:(83.05±12.40)%vs.(74.35±11.95)%,CRP(mg/L):141.21±71.02 vs.28.16±19.00,SA(mg/L):951.38±142.74 vs.726.80±135.60,all P<0.05].The AUC,sensitivity and specificity of WBC were 0.646,60.7%and 67.5%,the AUC,sensitivity and specificity of NEU were 0.683,67.9%and 65.0%,the AUC,sensitivity and specificity of NEU%were 0.732,66.1%and 70.0%,the AUC,sensitivity and specificity of CRP were 0.947,87.5%and 90.0%,and the AUC,sensitivity and specificity of SA were 0.877,92.9%and 72.5%,respectively.The diagnostic efficiencies of CRP and SA were significantly hi

关 键 词：新型冠状病毒感染 白细胞计数 中性粒细胞 C-反应蛋白 血清唾液酸 

分 类 号：R511[医药卫生—内科学]