恶唑烷酮/酰胺醇类耐药基因optrA研究进展  

Research Progress of Oxazolidinones/Phenicols-resistant Gene optrA

作　　者：叶超 张域琪 吴克 王娟[2] Ye Chao;Zhang Yu-qi;Wu Ke;Wang Juan(School of Animal Engineering,Yangling Vocational&Technical College,Yangling 712100;College of Veterinary Medicine,Northwest A&F University,Yangling 712100)

机构地区：[1]杨凌职业技术学院动物工程学院,陕西杨陵712100 [2]西北农林科技大学动物医学院,陕西杨陵712100

出　　处：《国外医药（抗生素分册）》2023年第3期155-159,共5页World Notes on Antibiotics

摘　　要：耐药基因optrA能够介导细菌对酰氨醇类抗生素如氯霉素、氟苯尼考和恶唑烷酮类抗生素如利奈唑胺、特地唑胺的耐药性。酰氨醇类药物是畜牧养殖业中用于预防和治疗细菌感染的主要抗生素;恶唑烷酮类药物则是人医临床上治疗多重耐药阳性菌株的最后一道防线。本研究综述了自2015年恶唑烷酮/酰胺醇类耐药基因optrA发现至今的相关文献资料,以期对optrA的研究进展作出总结。Antibiotic resistance gene(ARG)optrA mediates resistance against phenicols such as chloramphenicol and florfenicol,and oxazolidinones like linezolid and tedizolid.Phenicols is one of the main used antibiotics in domestic breeding for bacterial infection prevention.Moreover,oxazolidinones are the last-resort treatment for multidrug resistant gram-positive bacteria in clinical medicine.This study summarizes the relevant literature since the first discovery of oxazolidinones/phenicols-resistant gene optrA in 2015,with a view to summarizing the research progress of optrA.

关 键 词：恶唑烷酮类抗生素 酰氨醇类抗生素 optrA 耐药机制 流行特征 

分 类 号：R978.1[医药卫生—药品]