动物源分离菌异质性耐药研究进展  

Reviews on Heteroresistance of Bacteria Isolated from Animals

作　　者：赵冰 梁玉蕾 苑丽[1] Zhao Bing;Liang Yu-lei;Yuan Li(College of Veterinary Medicine,Henan Agricultural University,Zhengzhou 450046)

机构地区：[1]河南农业大学动物医学院,郑州450046

出　　处：《国外医药（抗生素分册）》2023年第3期173-177,共5页World Notes on Antibiotics

摘　　要：细菌耐药性的持续发展是全世界公共卫生难题,结果导致临床医学和畜牧业防控耐药菌感染日益困难,不仅严重威胁了人类健康,而且制约了畜牧业的健康持续发展。异质性耐药是细菌耐药发展的中间环节,在一定条件下能发展为稳定耐药菌,从而进一步加重细菌耐药;同时还会导致临床用药治疗失败,延长病程或影响养殖业的经济效益。本文从异质性耐药菌的分类、危害、检测方法与判定标准、流行病学特征及形成机制进行综述,以期为畜牧业临床诊断与研究异质性耐药菌提供理论依据,并为有效遏制细菌耐药发展提供帮助。The continuous development of bacterial resistance is a global public health problem.As a result,it is increasingly difficult to prevent and control drug-resistant bacterial infections in human medicine and animal husbandry,which not only seriously threatens human health,but also restricts the healthy and sustainable development of animal husbandry.Heteroresistance(HR)is an intermediate stage in the development of antibiotic resistance,which can develop into stable drug-resistant bacteria under certain conditions,thus further aggravating bacterial resistance.At the same time,it will lead to the failure of clinical drug treatment,prolong the course of disease or affect the economic benefits of stockbreeding.This article reviews the classification,harm,detection methods and criteria,epidemiological characteristics and formation mechanism of heteroresistant bacteria,in order to provide a theoretical basis for clinical diagnosis and research of heteroresistant bacteria in animal husbandry,as well as provide help for effectively curbing the development of drug resistance.

关 键 词：异质性耐药 形成机制 判定标准 流行病学特征 动物源细菌 检测方法 

分 类 号：R378[医药卫生—病原生物学]