细菌外膜囊泡介导水平基因转移机制研究进展  

Research Progress of Mechanisms of Bacterial Outer Membrane Vesicles Mediated Horizontal Gene Transfer

作　　者：李俊 李倩茹 吉星 何涛[1] 魏瑞成[1] 王冉[1] Li Jun;Li Qian-ru;Ji Xing;He Tao;Wei Rui-cheng;Wang Ran(Key Laboratory of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base,Key Laboratory of Agro-Product Safety Risk Evaluation(Nanjing)of Ministry of Agriculture and Rural Affairs,Institute of Agricultural Product Safety and Nutrition,Jiangsu Academy of Agricultural Sciences,Nanjing 210014;School of Animal Science and Technology,Guangxi University,Nanning 530004)

机构地区：[1]江苏省食品质量安全重点实验室-省部共建国家重点实验室培育基地,农业农村部农产品质量安全风险评估实验室,江苏省农业科学院农产品质量安全与营养研究所,南京210014 [2]广西大学动物科学技术学院,南宁530004

出　　处：《国外医药（抗生素分册）》2023年第3期178-184,共7页World Notes on Antibiotics

基　　金：国家自然科学基金项目(32102728);江苏省农业科学院探索性颠覆性创新项目(ZX(21)1224);江苏省自然科学基金(BK20200056);江苏省自主创新项目(CX(20)1011-1)。

摘　　要：细菌可以通过多种水平基因转移方式,如自然转化、转导、接合等,在微生物种群内交换遗传物质,进行细菌种内和种间交流。外膜囊泡是新发现的一种水平基因转移方式,它是细菌在自然生长过程中分泌的纳米级球状结构,可以作为载体携带核酸、酶、毒素和毒力因子等多种生物分子进行远距离运输。目前已有多项研究报道了细菌外膜囊泡的组成成分、生物合成和转移传播机制。本文就外膜囊泡在水平基因转移机制方面的研究进展进行综述。Bacteria have evolved many ways to horizontal transfer their genetic materials within the microbial world,such as natural transformation,transduction,conjugation,etc.Bacterial outer membrane vesicle is a newly found method for the horizontal gene transfer.Outer membrane vesicles are nanoscale spherical bag-like structures,released predominantly by bacteria during their growth and reproduction.Many kinds of biological molecules,such as nucleic acid,enzymes,toxins,virulence factors can be carried by outer membrane vesicles for long distance transmission.There has been many papers reporting the components,biosynthesis and transmission of outer membrane vesicles.This review summarized the recent progresses on the horizontal gene transfer of bacterial outer membrane vesicles.

关 键 词：细菌 外膜囊泡 生物发生 水平基因转移 耐药性 毒力 

分 类 号：R378[医药卫生—病原生物学]