肝脏类器官研究的文献计量学分析  

Bibliometric analysis of researches on liver organoids

作　　者：徐灿丽 何文星 汪磊[1] 吴芳婷 王佳慧 段雪琳 赵铁建 赵斌 郑洋 Xu Canli;He Wenxing;Wang Lei;Wu Fangting;Wang Jiahui;Duan Xuelin;Zhao Tiejian;Zhao Bin;Zheng Yang(Faculty of Chinese Medicine Science,Guangxi University of Chinese Medicine,Nanning 530200,Guangxi Zhuang Autonomous Region,China;College of Zhuang Medicine,Guangxi University of Chinese Medicine,Nanning 530200,Guangxi Zhuang Autonomous Region,China;College of Basic Medicine,Guangxi University of Chinese Medicine,Nanning 530200,Guangxi Zhuang Autonomous Region,China;Finance Office,Guangxi University of Chinese Medicine,Nanning 530200,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西中医药大学,赛恩斯新医药学院,广西壮族自治区南宁市530200 [2]广西中医药大学,壮医药学院,广西壮族自治区南宁市530200 [3]广西中医药大学,基础医学院,广西壮族自治区南宁市530200 [4]广西中医药大学,财务处,广西壮族自治区南宁市530200

出　　处：《中国组织工程研究》2024年第7期1099-1104,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(82204755),项目负责人:郑洋;国家自然科学基金项目(81960751),项目负责人:赵铁建;广西自然科学基金青年项目(2020GXNSFBA297094),项目负责人:郑洋;广西中医药大学赛恩斯新医药学院科研项目(2022CX004),项目负责人:赵斌;广西中医药大学赛恩斯新医药学院科研项目(2022MS002),项目负责人:汪磊;广西中医药大学赛恩斯新医药学院科研项目(2022MS008),项目负责人:郑洋;广西中医药大学赛恩斯新医药学院科研项目(2022QJ001),项目负责人:王佳慧。

摘　　要：背景:近些年,肝脏类器官的发展使其成为国际肝病研究领域的热点,但目前仍未有文献对其进行文献计量学分析。目的:基于文献计量学与可视化分析探索近20年肝脏类器官的热点趋势。方法:从Web of Science(科学网,WOS)核心合集中检索2002-01-01/2022-11-12肝脏类器官的相关文献,运行Origin、Office和CiteSpace软件进行文献计量与可视化分析,通过生成图表的方式来统计分析文献的年发文量、国家、机构、作者、期刊和关键词等内容。结果与结论:肝脏类器官研究领域近20年的发文量、被引频次、加入研究的机构和人员总体呈现上升趋势,说明该领域发展迅速关注度也逐渐升高。在该领域中,美国的发文量最多、影响力最强,虽然投入大量的时间与精力,但是在众多研究机构中美国单个研究机构的发文量并非最高;中国发文量仅次于美国,中国科学院和复旦大学是国内发文量最多的机构。荷兰乌得勒支大学是发文量最多的机构,发文量最高的作者是Clevers H,共引频次最高的文章是“Long-term culture of genome-stable bipotent stem cells from adult human liver”,分子学、生物学、免疫学是肝脏类器官研究的主流学科,出现次数最高的关键词包括stem cell(干细胞)、in vitro(体外)和culture(培养),肝脏类器官领域的研究热点主要集中在体外干细胞三维培养、分化及基因表达。BACKGROUND:In recent years,the development of liver organoids has made it a hot spot in the field of international liver disease research,but there is still no article on the bibliometric analysis of liver organoids.OBJECTIVE:To explore the hot trends in liver organoids in the last 20 years based on bibliometrics and visualization analysis.METHODS:We searched the articles about liver organoids in the Web of Science Core Collection from January 1,2002 to November 12,2022.Origin,Office,and CiteSpace software were used for bibliometrics and visualization analysis.We statistically analyzed the number of annually published articles,countries,institutions,authors,journals,and keywords of the articles by generating charts.RESULTS AND CONCLUSION:The number of articles,citation frequency,institutions and personnel involved in the research about liver organoids showed an overall upward trend in the last 20 years,indicating that the field was growing rapidly and attention was increasing.The USA had published the most papers and had the strongest influence in this field.Although it had invested a lot of time and energy,the number of papers published by a single research institution in the USA was not the highest among many research institutions.China was second only to the USA in the number of publications,with the Chinese Academy of Sciences and Fudan University leading the list.Utrecht University in the Netherlands was the institution with the most publications.Clevers H was the author with the highest number of articles.The article with the highest co-citation frequency was“Long-term culture of genome-stable bipotent stem cells from adult human liver”.The main fields of study for liver organoids were Molecular Science,Biology,and Immunology.The most frequently occurring keywords were stem cell,in vitro,and culture.The research hotspots in the liver organoids field were mainly focused on in vitro stem cell three-dimensional culture,differentiation and gene expression.

关 键 词：肝 类器官 文献计量学 前沿 热点 可视化 体外 干细胞 CITESPACE 

分 类 号：R459.9[医药卫生—治疗学] R318.14[医药卫生—临床医学] R617