骨骼肌再生过程中卫星细胞调控机制及其生态位信号的作用  

Mechanism of satellite cell regulation and its role in ecological niche signaling during skeletal muscle regeneration

作　　者：孔健达 穆玉晶 朱磊[1] 李志林 陈世娟 Kong Jianda;Mu Yujing;Zhu Lei;Li Zhilin;Chen Shijuan(School of Physical Education Science,Qufu Normal University,Jining 273100,Shandong Province,China;Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 100010,China;College of Physical Education Science,Tianjin Normal University,Tianjin 300380,China)

机构地区：[1]曲阜师范大学体育科学学院,山东省济宁市273100 [2]北京中医药大学东直门医院,北京市100010 [3]天津师范大学体育科学学院,天津市300380

出　　处：《中国组织工程研究》2024年第7期1105-1111,共7页Chinese Journal of Tissue Engineering Research

基　　金：山东省专业学位研究生教学案例库项目(SDYAL20103),项目负责人:朱磊。

摘　　要：背景:卫星细胞是骨骼肌包含的一种特定的成体干细胞群,可促进损伤骨骼肌的再生重建,但其具体机制尚不完善。目的:综述骨骼肌再生过程中卫星细胞调控作用以及卫星细胞与其生态位信号相互作用的机制,旨在总结现有知识的基础上提供新的研究思路和角度。方法:检索Web of Science、PubMed、中国知网(CNKI)、万方、维普等数据库2002年1月至2022年6月发表的文献。英文检索词:muscle,skeletal muscle,muscle injury,stem cells,satellite cells,muscle repair等;中文检索词:骨骼肌,骨骼肌再生,骨骼肌重建,卫星细胞,生态位等。共纳入66篇文献进行整理和分析。结果与结论:(1)卫星细胞存在于骨骼肌中,其既有助于损伤后新肌纤维的形成,亦有助于已存在的成年肌纤维有效生长。(2)卫星细胞中的静止卫星细胞被激活后,骨骼肌再生过程中卫星细胞的增殖、分化和融合形成肌纤维等步骤均会受到其内在不同机制调控作用的影响。(3)卫星细胞可与所处生态位信号中的肌纤维、细胞外基质、骨骼肌交界位、纤维生成祖细胞、免疫细胞以及内皮细胞相互作用促进卫星细胞的激活和增殖和分化,进而实现骨骼肌的有效再生。(4)未来研究可能的突破口:机体内卫星细胞的分裂模式;调控卫星细胞转移相关机制;卫星细胞在体内分化或自我更新的具体时间;卫星细胞和骨骼肌交界位的相互作用机制。(5)此次综述可为骨骼肌损伤重建的领域及其创新提供一定的理论参考价值。BACKGROUND:Satellite cells are a specific population of adult stem cells contained in skeletal muscle that promote the regenerative reconstruction of injured skeletal muscle,but their specific mechanisms are not well established.OBJECTIVE:To review the regulatory role of satellite cells during skeletal muscle regeneration and the mechanism of interaction between satellite cells and their ecological niche signals,aiming to provide new research ideas and perspectives based on the summary of existing knowledge.METHODS:Web of Science,PubMed,CNKI,WanFang,and VIP databases were searched for literature published between January 2002 and June 2022.English search terms were“muscle,skeletal muscle,muscle injury,stem cells,satellite cells,muscle repair”.Chinese search terms were“skeletal muscle,skeletal muscle regeneration,skeletal muscle reconstruction,satellite cells,ecological niche”.The 66 included papers were organized and analyzed.RESULTS AND CONCLUSION:(1)Satellite cells exist in skeletal muscle and contribute to both the formation of new muscle fibers after injury and the effective growth of existing adult muscle fibers.(2)After the activation of quiescent satellite cells in satellite cells,the steps of satellite cell proliferation,differentiation and fusion to form muscle fibers during skeletal muscle regeneration are influenced by their intrinsic regulatory effects of different mechanisms.(3)Satellite cells can interact with myofibers,extracellular matrix,skeletal muscle junctions,fibroblast progenitor cells,immune cells and endothelial cells in the ecological niche signal to promote satellite cell activation,proliferation and differentiation to achieve effective skeletal muscle regeneration.(4)Possible breakthroughs in future research include:the division pattern of satellite cells in the body;the mechanisms regulating satellite cell transfer;the specific timing of satellite cell differentiation or self-renewal in vivo;and the interaction mechanisms between satellite cells and skeletal muscle junctions.(5

关 键 词：骨骼肌 骨骼肌再生 卫星细胞 调控 生态位信号 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R87