自噬在毛发再生中的作用  

Role of autophagy in hair regeneration

作　　者：黄雨馨 梁文姿 陈秀文 倪娜 赵颖琳 林常敏[1] Huang Yuxin;Liang Wenzi;Chen Xiuwen;Ni Na;Zhao Yinglin;Lin Changmin(Medical College,Shantou University,Shantou 515041,Guangdong Province,China;Mental Health Center,Shantou University,Shantou 515065,Guangdong Province,China)

机构地区：[1]汕头大学医学院,广东省汕头市515041 [2]汕头大学精神卫生中心,广东省汕头市515065

出　　处：《中国组织工程研究》2024年第7期1112-1117,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金资助项目(007-41369023),项目负责人:林常敏。

摘　　要：背景:在生物医学界,自噬是一个快速发展的研究热点,许多研究人员正在积极探究多种疾病中自噬的分子调控机制,但是自噬在毛发生长中所起的作用仍存在许多未知。目的:综述目前自噬在毛发生长与再生中的研究进展及应用价值,了解自噬在毛发生长中的作用,以探究自噬在病理性脱发中的发病机制,为研究治疗脱发的药物提供新思路。方法:应用计算机在中国知网(CNKI)、PubMed数据库中,以“毛囊生长,毛发生长,毛发再生,自噬相关蛋白,自噬活性,自噬相关基因,自噬”或“hair growth,hair follicle,hair regeneration,autophagy”为检索词进行检索。查阅国内外近年来关于自噬、毛发生长和自噬在毛发生长中作用的研究进展进行总结,排除与文章主题内容不相符的文献,最终纳入78篇文献进行结果分析。结果与结论:(1)自噬是真核生物的正常代谢过程,具有复杂的分子机制和功能特性,既有利于细胞生存,又可促进细胞死亡。(2)脱发相关疾病与自噬活性的改变有关,且自噬活性可调控毛发生长周期;敲除或过表达自噬相关基因可改变毛发生长状态,已发现有多条自噬相关信号通路与毛囊生长有关;自噬的激活剂或抑制剂可用于治疗或预防脱发疾病。BACKGROUND:Autophagy has become a rapidly developing research hotspot in the biomedical fields.Many researchers are actively exploring the molecular regulatory mechanism of autophagy in a variety of diseases.However,the role of autophagy in hair growth is still unknown.OBJECTIVE:To review the current research progress and application value of autophagy in hair growth and regeneration,to understand the role of autophagy in hair growth,to explore the pathogenesis of autophagy in pathological hair loss,and to provide new ideas for the study of drugs for hair loss.METHODS:Using“hair follicle growth,hair growth,hair regeneration,autophagy associated proteins,autophagy activity,autophagy associated genes,autophagy”as Chinese search terms and“hair growth,hair follicle,hair regeneration,autophagy”as English search terms,PubMed and CNKI databases were searched.The research progress on autophagy,hair growth and the role of autophagy in hair growth in and outside China in recent years was reviewed and summarized.Articles incompatible with the subject content of the paper were excluded.Finally,78 articles were included for the result analysis.RESULTS AND CONCLUSION:(1)Autophagy is a normal metabolic process in eukaryotes with complex molecular mechanisms and functional properties,which is beneficial to cell survival and cell death.(2)Alopecia-related diseases are associated with changes in autophagy activity,which can regulate hair growth cycle.Knockout or overexpression of autophagy-related genes can change the state of hair growth.Multiple autophagy related signaling pathways have been found to be related to hair follicle growth.Activators or inhibitors of autophagy can be used to treat or prevent hair loss.

关 键 词：毛囊 毛发 毛发再生 毛囊再生 毛囊生长周期 自噬 自噬活性 自噬激活剂 自噬抑制剂 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R758.71