东莨菪碱和毒扁豆碱对吗啡训练大鼠空间学习的影响  

EFFECTS OF SCOPOLAMINE AND PHYSOSTIGMINUM ON SPATIAL LEARNING IN MORPHINE TRAINED RATS

作　　者：李新旺[1] 郑希耕[2] 杨晓燕[2] 隋南[2] 

机构地区：[1]河南大学心理系 [2]中国科学院心理研究所,北京100101

出　　处：《中国药物依赖性杂志》2002年第4期254-256,共3页Chinese Journal of Drug Dependence

基　　金：国家自然科学基金 (39970 2 5 6 ) ;中科院知识创新青年科学家小组;中科院知识创新工程项目 (KSCX2 - 2 - 0 3)

摘　　要：目的 :研究吗啡训练大鼠的空间学习障碍与胆碱能系统的关系。方法 :ip吗啡和其他药品 ;通过Morris水迷宫任务检测药物对吗啡训练大鼠空间学习的影响。结果 :10mg·kg- 1 的吗啡对大鼠学习空间任务具有显著的抑制作用 ;10mg·kg- 1 吗啡和 3mg·kg- 1 东莨菪碱联合给药 ,对大鼠学习空间任务的损害更加严重 ;0 .1mg·kg- 1 毒扁豆碱能够降低 10mg·kg- 1 吗啡对大鼠空间学习的影响。结论Objective : To investigate the relationship between the deficit of spatial learning in morphine trained rats and the function of cholingergic system. Methods : Using Morris water maze task; the rats received drug injections(ip)30 min before testing. Results : Morphine (10 mg·kg -1 ) significantly impaired the spatial learning capabilities; co-administration of morphine and scopolamine could aggravate the impairment of acquisition process in rats compared with morphine treatment. Physostigmine could attenuate the impairment of spatial acquisition capabilities induced by morphine administration. Conclusion : Morphine may induce the impairment of the spatial learning and one of the mechanisms is that morphine induces the function of cholingergic system.

关 键 词：MORRIS水迷宫 吗啡 东莨菪碱 毒扁豆碱 

分 类 号：R971.2[医药卫生—药品]