超脉冲CO_(2)激光联合磁敷疗法治疗浅表型增殖期婴幼儿血管瘤的临床效果及其对患儿血清EGFL7、HIF-1α、MMP9、TIMP-1水平的影响  

Clinical effect of ultrapulsed CO2 laser combined with magnetic application therapy for the treatment of superficial and proliferative infantile hemangioma and its influence on children′s serum EGFL7,HIF-1α,MMP9,and TIMP-1 levels

作　　者：郭粉娥[1] 李世英[1] 马军格[2] 郝乃猛 GUO Fene;LI Shiying;MA Junge;HAO Naimeng(Department of Rehabilitation Medicine,Handan Central Hospital,Handan 056001,Hebei,China;Department of Dermatology,Handan Central Hospital,Handan 056001,Hebei,China)

机构地区：[1]邯郸市中心医院康复医学科,河北省邯郸市056001 [2]邯郸市中心医院皮肤科,河北省邯郸市056001

出　　处：《广西医学》2023年第8期881-884,890,共5页Guangxi Medical Journal

摘　　要：目的探讨超脉冲CO_(2)激光联合磁敷疗法治疗浅表型增殖期婴幼儿血管瘤(IH)的临床效果及其对患儿血清表皮生长因子样结构域蛋白7(EGFL7)、缺氧诱导因子1α(HIF-1α)、基质金属蛋白酶9(MMP9)、组织金属蛋白酶抑制剂1(TIMP-1)水平的影响。方法将110例浅表型增殖期IH患儿随机分成观察组与对照组,各55例。观察组采用超脉冲CO_(2)激光联合磁敷疗法治疗,对照组采用单纯超脉冲CO_(2)激光治疗。比较两组患儿近期与远期治疗有效率,以及治疗前后的血清EGFL7、HIF-1α、MMP9、TIMP-1水平,观察两组患儿治疗期间不良反应的发生情况。结果观察组近期治疗有效率与远期治疗有效率均高于对照组(均P<0.05)。治疗后,两组患儿的血清EGFL7、HIF-1α、MMP9水平均低于治疗前,且观察组患儿的上述指标水平均低于对照组(均P<0.05);两组患儿的血清TIMP-1水平均高于治疗前,且观察组患儿的血清TIMP-1水平高于对照组(均P<0.05)。两组患儿治疗期间局部肿胀、局部红斑、色素沉着的发生率比较,差异均无统计学意义(均P>0.05)。结论相比于单纯超脉冲CO_(2)激光治疗,超脉冲CO_(2)激光联合磁敷疗法可提高浅表型增殖期IH患儿的治疗效果,安全性较高,其机制可能与调节血清EGFL7、HIF-1α、MMP9和TIMP-1水平有关。Objective To investigate the clinical effect of ultrapulsed CO_(2) laser combined with magnetic application therapy for the treatment of superficial and proliferative infantile hemangioma(IH),and its influence on children′s serum epidermal growth factor-like domain protein 7(EGFL7),hypoxia inducible factor 1α(HIF-1α),matrix metalloproteinase 9(MMP9),tissue inhibitor of metalloproteinase 1(TIMP-1)levels.Methods A total of 110 children with superficial and proliferative IH were randomly divided into observation group or control group,with 55 cases in each group.The observation group was treated with ultrapulsed CO_(2) laser combined with magnetic application therapy,whereas the control group was treated with ultrapulsed CO_(2) laser alone.The short-and long-term effective rates of treatment,and pre-and post-treatment serum EGFL7,HIF-1α,MMP9,and TIMP-1 levels of children were compared between the two groups.The occurrence of adverse reactions during treatment was observed in children of both groups.Results The short-and long-term effective rates of treatment in the observation group were higher than those in the control group(all P<0.05).After treatment,the levels of serum EGFL7,HIF-1α,and MMP9 of the two groups were lower than those before treatment,and the observation group yielded lower levels of aforesaid indices as compared with the control group(all P<0.05);furthermore,the level of serum TIMP-1 of the two groups was higher than that before treatment,and the observation group interpreted a higher serum TIMP-1 level as compared with the control group(all P<0.05).During treatment,there was no statistically significant difference in the incidence rates of localized swelling,localized erythema,and hyperpigmentation of children between the two groups(all P>0.05).Conclusion Compared with single ultrapulsed CO_(2) laser therapy,ultrapulsed CO_(2) laser combined with magnetic application therapy can improve therapeutic effect of children with superficial and proliferative IH,exerting a relatively high safety,and

关 键 词：婴幼儿血管瘤 超脉冲CO_(2)激光 磁敷疗法 疗效 表皮生长因子样结构域蛋白7 缺氧诱导因子1α 基质金属蛋白酶9 组织金属蛋白酶抑制剂1 

分 类 号：R729[医药卫生—儿科]