Atg介导的自噬、运动和骨骼肌衰老  

Atg-mediated autophagy,exercise and skeletal muscle aging

作　　者：王京峰 文登台 王士杰 高颖晖 Wang Jingfeng;Wen Dengtai;Wang Shijie;Gao Yinghui(College of Physical Education,Ludong University,Yantai 264025,Shandong Province,China)

机构地区：[1]鲁东大学,体育学院,山东省烟台市264025

出　　处：《中国组织工程研究》2024年第2期295-301,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(32000832),项目负责人:文登台;山东省自然科学基金(ZR2020QC096),项目负责人:文登台。

摘　　要：背景:运动作为一种可行的非药物治疗方法,有可能逆转随着年龄增长而恶化的骨骼肌衰老。自噬在骨骼肌衰老过程中的作用是不可缺少的。在骨骼肌衰老期间,参与调节自噬的Atg基因以或促进或抑制的方式调节自噬过程,以改善骨骼肌的生理形态。然而自噬在运动调节骨骼肌衰老中的具体分子机制仍令人困惑。目的:通过对该领域文献的回顾,寻找运动中自噬机制对骨骼肌衰老影响的一般规律。方法:①文献资料法:通过对CNKI及Web of Science数据库有关“Atg基因(蛋白)、自噬、运动以及骨骼肌衰老”等相关文献的检索、查阅和筛选,为全文的分析奠定理论基础。②对比分析法:通过对所得到文献进行阅读分析,比较文献之间的异同点,为论点提供合理的理论支撑;通过对文献的进一步对比分析,理清相关指标间的关系,为全文的分析明确思路。结果与结论:Atg家族介导的自噬对于延缓骨骼肌衰老是不可或缺的。参与调节自噬的Atg基因以或促进或抑制的方式调节自噬过程,以改善骨骼肌的生理形态及功能。不同的运动模式,如开始运动的年龄、时间或者强度,可能对自噬相关蛋白的表达有异质性的影响,但长期的有氧运动可以调节Atg相关蛋白,诱导骨骼肌自噬,并延缓肌肉质量的损失。BACKGROUND:Exercise as a viable non-pharmacological treatment has the potential to reverse skeletal muscle aging that deteriorates with age.The role of autophagy in the skeletal muscle aging process is indispensable.During skeletal muscle aging,Atg genes involved in regulating autophagy regulate the autophagic process in either a facilitative or inhibitory manner to improve the physiological morphology of skeletal muscle.However the specific molecular mechanisms of autophagy in the exercise regulation of skeletal muscle aging remain puzzling.OBJECTIVE:To search for general patterns of the effects of autophagic mechanisms on skeletal muscle aging during exercise through a review of articles in this field.METHODS:(1)CNKI and Web of Science were searched,reviewed,and screened for relevant literature using the keywords of”Atg genes(proteins),autophagy,exercise,and skeletal muscle aging”to lay the theoretical foundation for the full-text analysis.(2)The comparative analysis method was used to compare the similarities and differences among the included documents to provide reasonable theoretical support for the arguments.By the further comparative analysis of the literature,the relationship between relevant indicators was clarified,to provide the ideas for the full-text analysis.RESULTS AND CONCLUSION:Atg family-mediated autophagy is indispensable for delaying skeletal muscle aging.Atg genes involved in regulating autophagy regulate the autophagic process in either a facilitative or inhibitory manner to improve the physiological morphology and function of skeletal muscle.Different exercise patterns,such as age,time,or intensity at initiation,may have heterogeneous effects on the expression of autophagy-related proteins,but long-term aerobic exercise regulates Atg-related proteins,induces skeletal muscle autophagy,and delays the loss of muscle mass.

关 键 词：ATG 自噬 运动 骨骼肌衰老 有氧运动 

分 类 号：R455[医药卫生—运动医学] R318[医药卫生—治疗学] R807[医药卫生—临床医学]